Overseas Survey of the Effect of Cedrol on the Autonomic Nervous System in Three Countries

• Published in: Journal of PHYSIOLOGICAL ANTHROPOLOGY Vol. 26; no. 3; pp. 349 - 354
• Main Authors: Yada, Yukihiro, Sadachi, Hidetoshi, Nagashima, Yoshinao, Suzuki, Toshiyuki
• Format: Journal Article
• Language: English
• Published: England Japan Society of Physiological Anthropology 2007; BioMed Central
• Subjects: Administration, Inhalation; Adult; Aerosols; Asian Continental Ancestry Group - genetics; Autonomic Nervous System - drug effects; Autonomic Nervous System - physiology; cedarwood; cedrol; Coniferophyta; European Continental Ancestry Group - genetics; Female; Humans; Japan; Norway; parasympathetic nervous activities dominant; Phytotherapy; Stress, Physiological - drug therapy; Stress, Physiological - genetics; Surveys and Questionnaires; Terpenes - administration & dosage; Terpenes - therapeutic use; Thailand; the autonomic nervous system; Thailand; Norway; Japan
• ISSN: 1880-6791; 1880-6805
• DOI: 10.2114/jpa2.26.349

To clarify the influences of ethnic and regional characteristics, and differences in perception on the cedrol effect on autonomic nerve activity, we compared women in their 20s–40s in Norway, Thailand, and Japan. A questionnaire survey of sense of stress and sleep conditions was performed at the same time. The degree of perceived stress, using a 30-item checklist, was highest in Japanese women. The mean stress score exceeded 5.0 in Japanese women, significantly higher than in Thai women (p<0.05) and Norwegian women (p<0.01). Sleeping time was shortest in Japanese women in all generations among the three countries. As the index of autonomic nervous activity, the miosis rate (ratio of pupil-diameter variation after light stimulus to initial pupil diameter) in pupillary light reflex was measured before and after cedrol inhalation. The miosis rate significantly increased after cedrol exposure compared to that before exposure in all three countries, suggesting that the parasympathetic nervous system became dominant. These findings suggested that cedrol produces a sedative effect in people of the three countries despite differences in the ethnic and living environments.