Hypoxia and hypoxia inducible factors: Diverse roles in liver diseases

Hypoxia has been shown to have a role in the pathogenesis of several forms of liver disease. The hypoxia inducible factors (HIFs) are a family of evolutionarily conserved transcriptional regulators that affect a homeostatic response to low oxygen tension and have been identified as key mediators of...

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Published in:	Hepatology (Baltimore, Md.) Vol. 55; no. 2; pp. 622 - 633
Main Authors:	Nath, Bharath, Szabo, Gyongyi
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01-02-2012 Wiley Wiley Subscription Services, Inc
Subjects:	Acetaminophen - poisoning Animals Biological and medical sciences Gastroenterology. Liver. Pancreas. Abdomen Hepatology Humans Hypoxia Hypoxia - complications Hypoxia - metabolism Hypoxia-Inducible Factor 1 - metabolism Immunity, Innate Lipid Metabolism Liver - drug effects Liver - metabolism Liver cirrhosis Liver diseases Liver Diseases - etiology Liver Diseases - metabolism Liver Regeneration Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Metals - metabolism Oxygen - metabolism Reperfusion Injury - metabolism Sleep Apnea, Obstructive - metabolism Digestive diseases Hypoxia Hepatic disease Oxygen Gastroenterology
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Abstract	Hypoxia has been shown to have a role in the pathogenesis of several forms of liver disease. The hypoxia inducible factors (HIFs) are a family of evolutionarily conserved transcriptional regulators that affect a homeostatic response to low oxygen tension and have been identified as key mediators of angiogenesis, inflammation, and metabolism. In this review we summarize the evidence for a role of HIFs across a range of hepatic pathophysiology. We describe regulation of the HIFs and review investigations that demonstrate a role for HIFs in the development of liver fibrosis, activation of innate immune pathways, hepatocellular carcinoma, as well as other liver diseases in both human disease as well as murine models. (HEPATOLOGY 2012;)
AbstractList	Hypoxia has been shown to have a role in the pathogenesis of several forms of liver disease. The hypoxia inducible factors (HIFs) are a family of evolutionarily conserved transcriptional regulators that affect a homeostatic response to low oxygen tension and have been identified as key mediators of angiogenesis, inflammation, and metabolism. In this review we summarize the evidence for a role of HIFs across a range of hepatic pathophysiology. We describe regulation of the HIFs and review investigations that demonstrate a role for HIFs in the development of liver fibrosis, activation of innate immune pathways, hepatocellular carcinoma, as well as other liver diseases in both human disease as well as murine models. (HEPATOLOGY 2012; ) Hypoxia has been shown to have a role in the pathogenesis of several forms of liver disease. The hypoxia inducible factors (HIFs) are a family of evolutionarily conserved transcriptional regulators that affect a homeostatic response to low oxygen tension and have been identified as key mediators of angiogenesis, inflammation, and metabolism. In this review we summarize the evidence for a role of HIFs across a range of hepatic pathophysiology. We describe regulation of the HIFs and review investigations that demonstrate a role for HIFs in the development of liver fibrosis, activation of innate immune pathways, hepatocellular carcinoma, as well as other liver diseases in both human disease as well as murine models. Hypoxia has been shown to have a role in the pathogenesis of several forms of liver disease. The Hypoxia Inducible Factors (HIFs) are a family of evolutionarily conserved transcriptional regulators that affect a homeostatic response to low oxygen tension and have been identified as key mediators of angiogenesis, inflammation, and metabolism. In this review, we summarize the evidence for a role of HIFs across a range of hepatic pathophysiology. We describe regulation of the hypoxia inducible factors and review investigations that demonstrate a role for HIFs in the development of liver fibrosis, activation of innate immune pathways, hepatocellular carcinoma, as well as other liver diseases in both human disease as well as murine models.
Author	Szabo, Gyongyi Nath, Bharath
Author_xml	– sequence: 1 givenname: Bharath surname: Nath fullname: Nath, Bharath organization: Department of Medicine, University of Massachusetts Medical School, Worcester, MA – sequence: 2 givenname: Gyongyi surname: Szabo fullname: Szabo, Gyongyi email: gyongyi.szabo@umassmed.edu organization: Department of Medicine, University of Massachusetts Medical School, Worcester, MA
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Notes	ark:/67375/WNG-W4JNLK2J-3 istex:D55F4F078BEF3300EE2C75817EC9AE3AFE335D8C Potential conflict of interest: Dr. Szabo is a consultant for, advises, and is on the speakers' bureau of Vertex, Conatus, GlaxoSmithKline, Bristol-Myers Squibb, Idenix, Idera, Integrated Therapeutics, Johnson & Johnson, Novartis, Novelos, Ocera, Roche, Schering-Plough, Wyeth, SmithKline Beechman, Ikaria, and FALK. ArticleID:HEP25497 Potential conflict of interest: Dr. Szabo is a consultant for, advises, and is on the speakers' bureau of Vertex, Conatus, GlaxoSmithKline, Bristol‐Myers Squibb, Idenix, Idera, Integrated Therapeutics, Johnson & Johnson, Novartis, Novelos, Ocera, Roche, Schering‐Plough, Wyeth, SmithKline Beechman, Ikaria, and FALK. fax: 508‐856‐4770 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
OpenAccessLink	https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.25497
PMID	22120903
PQID	1766825557
PQPubID	996352
PageCount	12
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_3417333 proquest_miscellaneous_1776646538 proquest_journals_1766825557 crossref_primary_10_1002_hep_25497 pubmed_primary_22120903 pascalfrancis_primary_25589056 wiley_primary_10_1002_hep_25497_HEP25497 istex_primary_ark_67375_WNG_W4JNLK2J_3
PublicationCentury	2000
PublicationDate	February 2012
PublicationDateYYYYMMDD	2012-02-01
PublicationDate_xml	– month: 02 year: 2012 text: February 2012
PublicationDecade	2010
PublicationPlace	Hoboken
PublicationPlace_xml	– name: Hoboken – name: Hoboken, NJ – name: United States
PublicationTitle	Hepatology (Baltimore, Md.)
PublicationTitleAlternate	Hepatology
PublicationYear	2012
Publisher	Wiley Subscription Services, Inc., A Wiley Company Wiley Wiley Subscription Services, Inc
Publisher_xml	– name: Wiley Subscription Services, Inc., A Wiley Company – name: Wiley – name: Wiley Subscription Services, Inc
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Snippet	Hypoxia has been shown to have a role in the pathogenesis of several forms of liver disease. The hypoxia inducible factors (HIFs) are a family of... Hypoxia has been shown to have a role in the pathogenesis of several forms of liver disease. The Hypoxia Inducible Factors (HIFs) are a family of...
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SubjectTerms	Acetaminophen - poisoning Animals Biological and medical sciences Gastroenterology. Liver. Pancreas. Abdomen Hepatology Humans Hypoxia Hypoxia - complications Hypoxia - metabolism Hypoxia-Inducible Factor 1 - metabolism Immunity, Innate Lipid Metabolism Liver - drug effects Liver - metabolism Liver cirrhosis Liver diseases Liver Diseases - etiology Liver Diseases - metabolism Liver Regeneration Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Metals - metabolism Oxygen - metabolism Reperfusion Injury - metabolism Sleep Apnea, Obstructive - metabolism
Title	Hypoxia and hypoxia inducible factors: Diverse roles in liver diseases
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