Gut bacterial deamination of residual levodopa medication for Parkinson’s disease

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by both motor and non-motor symptoms. Gastrointestinal tract dysfunction is one of the non-motor features, where constipation is reported as the most common gastrointestinal symptom. Aromatic bacterial metabolite...

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Bibliographic Details
Published in:	BMC biology Vol. 18; no. 1; pp. 1 - 137
Main Authors:	van Kessel, Sebastiaan P, de Jong, Hiltje R, Winkel, Simon L, van Leeuwen, Sander S, Nelemans, Sieger A, Permentier, Hjalmar, Keshavarzian, Ali, El Aidy, Sahar
Format:	Journal Article
Language:	English
Published:	London BioMed Central Ltd 20-10-2020 BioMed Central BMC
Subjects:	Amino acids Aminotransferase Analysis Bacteria Bioactive compounds Bioactive metabolites Clostridium sporogenes Constipation Deamination Digestive system Drug metabolism Drug side effects Enzymes Gastric motility Gastrointestinal motility Gastrointestinal symptoms Gastrointestinal system Gastrointestinal tract Homeostasis Intestinal microflora L-dopa Levodopa Medical treatment Metabolic pathways Metabolites Microbiomes Microbiota Microbiota (Symbiotic organisms) Motility Movement disorders Neurodegenerative diseases Non-motor symptoms Ostomy Parkinson's disease Physiological aspects Polyphenols Propionic acid Resveratrol Side effects
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