Coding polymorphisms in Casp5, Casp8 and DR4 genes may play a role in predisposition to lung cancer

Abstract Apoptosis plays a role in the elimination of DNA-damaged cells thus protecting the host from cancer development. Some data indicate that normal variations within the sequence of apoptotic genes may lead to suboptimal apoptotic capacity and therefore increased cancer risk. We tested 19 codin...

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Bibliographic Details
Published in:	Cancer letters Vol. 278; no. 2; pp. 183 - 191
Main Authors:	Ulybina, Yulia M, Kuligina, Ekatherina Sh, Mitiushkina, Nathalia V, Rozanov, Maxim E, Ivantsov, Alexandr O, Ponomariova, Daria N, Togo, Alexandr V, Levchenko, Evgeny V, Shutkin, Vladimir A, Brenister, Sergiu I, Devilee, Peter, Zhivotovsky, Boris, Hirvonen, Ari, Imyanitov, Evgeny N
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier B.V 18-06-2009 Elsevier Limited
Subjects:	Adult Age Aged Aged, 80 and over Apoptosis Caspase 8 - genetics Caspases - genetics Confidence intervals Deoxyribonucleic acid DNA DNA repair Gene polymorphisms Genes Genetic Predisposition to Disease Genetic testing Hematology, Oncology and Palliative Medicine Humans Lung cancer Lung Neoplasms - etiology Lung Neoplasms - genetics Medicin och hälsovetenskap Middle Aged Mortality Polymorphism, Single Nucleotide Predisposition Receptors, TNF-Related Apoptosis-Inducing Ligand Receptors, Tumor Necrosis Factor - genetics Smoking Studies Gene polymorphisms Lung cancer Predisposition Apoptosis
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