Signaling pathways in schizophrenia: emerging targets and therapeutic strategies

Dopamine D2 receptor antagonism is a unifying property of all antipsychotic drugs in use for schizophrenia. While often effective at ameliorating psychosis, these drugs are largely ineffective at treating negative and cognitive symptoms. Increasing attention is being focused on the complex genetics...

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Bibliographic Details

Published in:	Trends in pharmacological sciences (Regular ed.) Vol. 31; no. 8; pp. 381 - 390
Main Authors:	Karam, Caline S, Ballon, Jacob S, Bivens, Nancy M, Freyberg, Zachary, Girgis, Ragy R, Lizardi-Ortiz, José E, Markx, Sander, Lieberman, Jeffrey A, Javitch, Jonathan A
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-08-2010
Subjects:	Advanced Basic Science Animals Antipsychotic Agents - pharmacology Dopamine D2 Receptor Antagonists Drug Delivery Systems Drug Design Humans Schizophrenia - drug therapy Schizophrenia - genetics Schizophrenia - physiopathology Signal Transduction - drug effects
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