Inactivation of Vibrio vulnificus hemolysin through mutation of the N- or C-terminus of the lectin-like domain

Vibrio vulnificus is an etiological agent causing serious systemic infections in the immunocompromised humans or cultured eels. This species commonly produces a hemolytic toxin consisting of the cytolysin domain and the lectin-like domain. For hemolysis, the lectin-like domain specifically binds to...

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Bibliographic Details
Published in:	Toxicon (Oxford) Vol. 57; no. 6; pp. 904 - 908
Main Authors:	Miyoshi, Shin-ichi, Abe, Yuki, Senoh, Mitsutoshi, Mizuno, Tamaki, Maehara, Yoko, Nakao, Hiroshi
Format:	Journal Article
Language:	English
Published:	Kidlington Elsevier Ltd 01-05-2011 Elsevier
Subjects:	amino acids Animal poisons toxicology. Antivenoms Bacterial Proteins - genetics Bacterial Proteins - metabolism Biological and medical sciences Blotting, Western Cell Membrane - metabolism Cell-free translation cholesterol Cholesterol - metabolism eel erythrocytes Erythrocytes - metabolism etiological agents Hemolysin Hemolysin Proteins - genetics Hemolysin Proteins - metabolism hemolysis immunocompromised population Medical sciences Mutagenesis mutation Mutation - genetics Polymerase Chain Reaction Protein Structure, Tertiary - genetics Site-directed mutagenesis Toxicology Vibrio vulnificus Vibrio vulnificus - chemistry Hemolysin Cell-free translation Site-directed mutagenesis Vibrio vulnificus Lectin Mutagenesis Bacteria Vibrionaceae Mutation Inactivation Genetic translation
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