Hemokinin-1 mediates pruriceptive processing in the rat spinal cord

Highlights • [Leu11 ]-HK-1 attenuated the induction of scratching by HK-1, but not SP. • Formalin-induced flinching was attenuated by [Leu11 ]-SP, but not [Leu11 ]-HK-1. • [Leu11 ]-HK-1 attenuated the induction of scratching by 5-HT and histamine. • HK-1 may contribute to pruritic processing....

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Bibliographic Details
Published in:	Neuroscience Vol. 277; pp. 206 - 216
Main Authors:	Funahashi, H, Naono-Nakayama, R, Ebihara, K, Koganemaru, G, Kuramashi, A, Ikeda, T, Nishimori, T, Ishida, Y
Format:	Journal Article
Language:	English
Published:	United States Elsevier Ltd 26-09-2014
Subjects:	[Leu11]-hemokinin-1 Animals Disease Models, Animal Formaldehyde Histamine Immunohistochemistry Male Neurology Nociception - drug effects Nociception - physiology Pain - metabolism Proto-Oncogene Proteins c-fos - metabolism pruritus Pruritus - drug therapy Pruritus - metabolism rat Rats, Sprague-Dawley Serotonin spinal cord Spinal Cord - drug effects Spinal Cord - metabolism Substance P - metabolism Tachykinins - metabolism pruritus histamine GRP rat HK-1 neurokinin 1 natriuretic polypeptide b Nppb serotonin hemokinin-1 NK1 [Leu 11]-hemokinin-1 gastrin-releasing peptide endokinin C and endokinin D spinal cord 5-HT substance P EKC/D SP [Leu11]-hemokinin-1 [Leu]-hemokinin-1
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Summary:	Highlights • [Leu11 ]-HK-1 attenuated the induction of scratching by HK-1, but not SP. • Formalin-induced flinching was attenuated by [Leu11 ]-SP, but not [Leu11 ]-HK-1. • [Leu11 ]-HK-1 attenuated the induction of scratching by 5-HT and histamine. • HK-1 may contribute to pruritic processing.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.07.001