P63 targeted deletion under the FOXN1 promoter disrupts pre-and post-natal thymus development, function and maintenance as well as induces severe hair loss

Progressive immune deficiency of aging is characterized by severe thymic atrophy, contracted T cell repertoire, and poor immune function. p63 is critical for the proliferative potential of embryonic and adult stem cells, as well as thymic epithelial cells (TECs). Because p63 null mice experience rap...

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Bibliographic Details
Published in:	PloS one Vol. 17; no. 1; p. e0261770
Main Authors:	Stefanski, Heather E, Xing, Yan, Nicholls, Jemma, Jonart, Leslie, Goren, Emily, Taylor, Patricia A, Mills, Alea A, Riddle, Megan, McGrath, John, Tolar, Jakub, Hollander, Georg A, Blazar, Bruce R
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 25-01-2022 Public Library of Science (PLoS)
Subjects:	Aging Alopecia Alopecia - genetics Alopecia - metabolism Animals Antibodies Apoptosis Atrophy Baldness Biology and Life Sciences Defects Dermatology Development Embryo cells Embryogenesis Engineering and Technology Epithelial cells Epithelium Fetus Flow cytometry Follicles Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Gene Deletion Gene Knockout Techniques Genetic aspects Growth Hair Health aspects Hypoplasia Immune response Immunological deficiency syndromes Infants Laboratories Lethality Lymphocytes Lymphocytes T Lymphopenia Maintenance Medicine and Health Sciences Mice Mice, Knockout Morphogenesis Neonates Pediatric research Pediatrics Physiological aspects Promoter Regions, Genetic Research and Analysis Methods Risk factors Skin Stem cell transplantation Stem cells Thymic hypoplasia Thymus Thymus gland Thymus Gland - growth & development Trans-Activators - deficiency Trans-Activators - metabolism Transcription factors United States Minneapolis Minnesota New York United States > US Switzerland Japan
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