A positive feedback loop between mTORC1 and cathelicidin promotes skin inflammation in rosacea

Rosacea is a chronic inflammatory skin disorder whose pathogenesis is unclear. Here, several lines of evidence were provided to demonstrate that mTORC1 signaling is hyperactivated in the skin, especially in the epidermis, of both rosacea patients and a mouse model of rosacea‐like skin inflammation....

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Bibliographic Details
Published in:	EMBO molecular medicine Vol. 13; no. 5; pp. e13560 - n/a
Main Authors:	Deng, Zhili, Chen, Mengting, Liu, Yingzi, Xu, San, Ouyang, Yuyan, Shi, Wei, Jian, Dan, Wang, Ben, Liu, Fangfen, Li, Jinmao, Shi, Qian, Peng, Qinqin, Sha, Ke, Xiao, Wenqin, Liu, Tangxiele, Zhang, Yiya, Zhang, Hongbing, Wang, Qian, Sun, Lunquan, Xie, Hongfu, Li, Ji
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 07-05-2021 EMBO Press John Wiley and Sons Inc Springer Nature
Subjects:	Ablation Animals Antimicrobial agents Antimicrobial Cationic Peptides Biopsy Chemokines Cytokines Disease EMBO19 EMBO38 Epidermis Epithelium Feedback Genes Humans Inflammation Keratinocytes Kinases LL37 Mammals Mechanistic Target of Rapamycin Complex 1 Mice mTOR Pathogenesis Patients Protein synthesis Proteins Rapamycin Rosacea Rosacea - drug therapy Skin diseases skin inflammation TLR2 protein Toll-like receptors Topical application mTOR Rapamycin rosacea skin inflammation LL37
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