Anti-CRISPR-mediated control of gene editing and synthetic circuits in eukaryotic cells

Repurposed CRISPR-Cas molecules provide a useful tool set for broad applications of genomic editing and regulation of gene expression in prokaryotes and eukaryotes. Recent discovery of phage-derived proteins, anti-CRISPRs, which serve to abrogate natural CRISPR anti-phage activity, potentially expan...

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Bibliographic Details
Published in:	Nature communications Vol. 10; no. 1; p. 194
Main Authors:	Nakamura, Muneaki, Srinivasan, Prashanth, Chavez, Michael, Carter, Matthew A., Dominguez, Antonia A., La Russa, Marie, Lau, Matthew B., Abbott, Timothy R., Xu, Xiaoshu, Zhao, Dehua, Gao, Yuchen, Kipniss, Nathan H., Smolke, Christina D., Bondy-Denomy, Joseph, Qi, Lei S.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 14-01-2019 Nature Publishing Group Nature Portfolio
Subjects:	13/106 13/31 14 14/63 42/109 631/337/4041 631/61/338/552 Bacteriophages - genetics Cell Culture Techniques Clustered Regularly Interspaced Short Palindromic Repeats - genetics CRISPR-Cas Systems - genetics Crystal defects Crystals Eukaryotic Cells Gene Editing - methods Gene Regulatory Networks - genetics Genetic Vectors - genetics Genome editing HEK293 Cells Humanities and Social Sciences Humans Image resolution Induced Pluripotent Stem Cells Intravital Microscopy - methods Lentivirus - genetics Low temperature Luminescence Microscopy, Fluorescence - methods multidisciplinary Nanotechnology Nanowires Perovskites Phages Phase transitions Science Science (multidisciplinary) Spectroscopic analysis Spectroscopy Temperature effects Time-Lapse Imaging - methods Transduction, Genetic - methods Transfection - methods Transition temperature
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