Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A

Inhibitors of the secretion of cancer exosomes, which promote cancer progression and metastasis, may not only accelerate exosome biology research but also offer therapeutic benefits for cancer patients. Here we identify sulfisoxazole (SFX) as an inhibitor of small extracellular vesicles (sEV) secret...

Full description

Saved in:

Bibliographic Details
Published in:	Nature communications Vol. 10; no. 1; pp. 1387 - 17
Main Authors:	Im, Eun-Ju, Lee, Chan-Hyeong, Moon, Pyong-Gon, Rangaswamy, Gunassekaran Gowri, Lee, Byungheon, Lee, Jae Man, Lee, Jae-Chul, Jee, Jun-Goo, Bae, Jong-Sup, Kwon, Taeg-Kyu, Kang, Keon-Wook, Jeong, Myeong-Seon, Lee, Joo-Eun, Jung, Hyun-Suk, Ro, Hyun-Joo, Jun, Sangmi, Kang, Wonku, Seo, Seung-Yong, Cho, Young-Eun, Song, Byoung-Joon, Baek, Moon-Chang
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 27-03-2019 Nature Publishing Group Nature Portfolio
Subjects:	14/1 38/1 38/61 49/98 631/67/1059/153 631/67/1347 631/80/313/2376 82/29 82/58 96/1 96/63 Animal models Animals Anti-Infective Agents - pharmacology Antibiotics Anticancer properties Biology Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cell Line, Tumor Endosomes Endosomes - drug effects Endosomes - metabolism Endothelins Exosomes Extracellular vesicles Extracellular Vesicles - drug effects Extracellular Vesicles - metabolism Female Humanities and Social Sciences Humans Localization Lysosomes Lysosomes - drug effects Lysosomes - metabolism Male MCF-7 Cells Metastases Mice Mice, Nude multidisciplinary Neoplasm Metastasis Organelle Biogenesis Pharmacology Proteins Receptor, Endothelin A - drug effects Receptor, Endothelin A - metabolism Science Science (multidisciplinary) Secretion Sulfisoxazole Sulfisoxazole - pharmacology Vesicles Xenograft Model Antitumor Assays Xenografts Xenotransplantation
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!