Impairment of intermediate somatosensory function in corticobasal syndrome

• Published in: Scientific reports Vol. 10; no. 1; pp. 11155 - 8
• Main Authors: Matsuda, Kana, Satoh, Masayuki, Tabei, Ken-ichi, Ueda, Yukito, Taniguchi, Akira, Matsuura, Keita, Asahi, Masaru, Ii, Yuichiro, Niwa, Atsushi, Tomimoto, Hidekazu
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07-07-2020; Nature Publishing Group; Nature Portfolio
• Subjects: 692/617/375/364; 692/617/375/365; Aged; Atrophy; Brain - diagnostic imaging; Brain - pathology; Brain - physiopathology; Female; Gray Matter - diagnostic imaging; Gray Matter - pathology; Gray Matter - physiopathology; Humanities and Social Sciences; Humans; Magnetic Resonance Imaging; Male; Morphometry; Movement disorders; multidisciplinary; Neurodegenerative diseases; Neurodegenerative Diseases - diagnostic imaging; Neurodegenerative Diseases - pathology; Neurodegenerative Diseases - physiopathology; Neuroimaging; Neuropsychological Tests; Parkinson Disease - pathology; Parkinson Disease - physiopathology; Parkinson's disease; Science; Science (multidisciplinary); Somatosensory Disorders - diagnostic imaging; Somatosensory Disorders - etiology; Somatosensory Disorders - pathology; Somatosensory Disorders - physiopathology; Substantia grisea; Supplementary motor area; Syndrome; Tactile discrimination
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-020-67991-7

Corticobasal syndrome (CBS) is characterized by unilateral atrophy of the brain. New diagnostic criteria for CBS include intermediate somatosensory dysfunction. Here, we aimed to carefully examine intermediate somatosensory function to identify tests which can assess impairment in CBS patients. Using voxel-based morphometry (VBM), we also aimed to show the anatomical bases of these impairments. Subjects included 14 patients diagnosed with CBS and 14 patients with Parkinson's disease (PD). Patients were evaluated using intermediate somatosensory tests and neuropsychological assessments. VBM was used to analyze differences in gray matter volumes between CBS and PD patients. In the PD group, no tests showed a significant difference between the dominant-side onset and the non-dominant-side onset. In the CBS group, all tests showed worse scores on the affected side. For detecting intermediate somatosensory dysfunction in CBS, two tests are recommended: tactile object naming and 2-point discrimination. VBM analysis showed that the volume of the left post- and pre-central gyrus, and both sides of the supplementary motor area were significantly decreased in the CBS group compared to the PD group. Although CBS remains untreatable, early and correct diagnosis is possible by performing close examination of intermediate somatosensory function.