Tissue-resident Eomes+ NK cells are the major innate lymphoid cell population in human infant intestine

Innate lymphoid cells (ILC), including natural killer (NK) cells, are implicated in host-defense and tissue-growth. However, the composition and kinetics of NK cells in the intestine during the first year of life, when infants are first broadly exposed to exogenous antigens, are still unclear. Here...

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Published in:	Nature communications Vol. 10; no. 1; p. 975
Main Authors:	Sagebiel, Adrian F., Steinert, Fenja, Lunemann, Sebastian, Körner, Christian, Schreurs, Renée R. C. E., Altfeld, Marcus, Perez, Daniel, Reinshagen, Konrad, Bunders, Madeleine J.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 28-02-2019 Nature Publishing Group Nature Portfolio
Subjects:	13/1 13/31 631/250/1619/382 631/250/2504/2506 631/250/347 692/4020/2741/520 Adult Adults Aged Antigens Antigens, CD - metabolism Babies CD103 antigen CD69 antigen Cytotoxicity Degranulation Effector cells Granzyme B Granzymes - metabolism Humanities and Social Sciences Humans Immunity, Innate Immunophenotyping Infant Infants Integrin alpha Chains - metabolism Intestine Intestines - cytology Intestines - growth & development Intestines - immunology Killer Cells, Natural - classification Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Kinetics Lymphocytes Lymphocytes T Lymphoid cells Middle Aged multidisciplinary Natural killer cells NK Cell Lectin-Like Receptor Subfamily C - metabolism Perforin Perforin - metabolism Phenotypes Science Science (multidisciplinary) T-Box Domain Proteins - metabolism Tissue Distribution Tissues
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Abstract	Innate lymphoid cells (ILC), including natural killer (NK) cells, are implicated in host-defense and tissue-growth. However, the composition and kinetics of NK cells in the intestine during the first year of life, when infants are first broadly exposed to exogenous antigens, are still unclear. Here we show that CD103 + NK cells are the major ILC population in the small intestines of infants. When compared to adult intestinal NK cells, infant intestinal NK cells exhibit a robust effector phenotype, characterized by Eomes, perforin and granzyme B expression, and superior degranulation capacity. Absolute intestinal NK cell numbers decrease gradually during the first year of life, coinciding with an influx of intestinal Eomes + T cells; by contrast, epithelial NKp44 + CD69 + NK cells with less cytotoxic capacity persist in adults. In conclusion, NK cells are abundant in infant intestines, where they can provide effector functions while Eomes + T cell responses mature. Innate lymphoid cells (ILC), including natural killer (NK) cells, are important innate immune regulators. Here the authors show that, in human infant intestines, CD103 + Eomes + NK cells are the predominant ILC population, but are replaced gradually by Eomes + T cells, while NKp44 + NK cells persist in adult intestines.
AbstractList	Innate lymphoid cells (ILC), including natural killer (NK) cells, are important innate immune regulators. Here the authors show that, in human infant intestines, CD103+Eomes+ NK cells are the predominant ILC population, but are replaced gradually by Eomes+ T cells, while NKp44+ NK cells persist in adult intestines. Innate lymphoid cells (ILC), including natural killer (NK) cells, are implicated in host-defense and tissue-growth. However, the composition and kinetics of NK cells in the intestine during the first year of life, when infants are first broadly exposed to exogenous antigens, are still unclear. Here we show that CD103+ NK cells are the major ILC population in the small intestines of infants. When compared to adult intestinal NK cells, infant intestinal NK cells exhibit a robust effector phenotype, characterized by Eomes, perforin and granzyme B expression, and superior degranulation capacity. Absolute intestinal NK cell numbers decrease gradually during the first year of life, coinciding with an influx of intestinal Eomes+ T cells; by contrast, epithelial NKp44+CD69+ NK cells with less cytotoxic capacity persist in adults. In conclusion, NK cells are abundant in infant intestines, where they can provide effector functions while Eomes+ T cell responses mature.Innate lymphoid cells (ILC), including natural killer (NK) cells, are important innate immune regulators. Here the authors show that, in human infant intestines, CD103+Eomes+ NK cells are the predominant ILC population, but are replaced gradually by Eomes+ T cells, while NKp44+ NK cells persist in adult intestines. Innate lymphoid cells (ILC), including natural killer (NK) cells, are implicated in host-defense and tissue-growth. However, the composition and kinetics of NK cells in the intestine during the first year of life, when infants are first broadly exposed to exogenous antigens, are still unclear. Here we show that CD103 + NK cells are the major ILC population in the small intestines of infants. When compared to adult intestinal NK cells, infant intestinal NK cells exhibit a robust effector phenotype, characterized by Eomes, perforin and granzyme B expression, and superior degranulation capacity. Absolute intestinal NK cell numbers decrease gradually during the first year of life, coinciding with an influx of intestinal Eomes + T cells; by contrast, epithelial NKp44 + CD69 + NK cells with less cytotoxic capacity persist in adults. In conclusion, NK cells are abundant in infant intestines, where they can provide effector functions while Eomes + T cell responses mature. Innate lymphoid cells (ILC), including natural killer (NK) cells, are implicated in host-defense and tissue-growth. However, the composition and kinetics of NK cells in the intestine during the first year of life, when infants are first broadly exposed to exogenous antigens, are still unclear. Here we show that CD103 + NK cells are the major ILC population in the small intestines of infants. When compared to adult intestinal NK cells, infant intestinal NK cells exhibit a robust effector phenotype, characterized by Eomes, perforin and granzyme B expression, and superior degranulation capacity. Absolute intestinal NK cell numbers decrease gradually during the first year of life, coinciding with an influx of intestinal Eomes + T cells; by contrast, epithelial NKp44 + CD69 + NK cells with less cytotoxic capacity persist in adults. In conclusion, NK cells are abundant in infant intestines, where they can provide effector functions while Eomes + T cell responses mature. Innate lymphoid cells (ILC), including natural killer (NK) cells, are important innate immune regulators. Here the authors show that, in human infant intestines, CD103 + Eomes + NK cells are the predominant ILC population, but are replaced gradually by Eomes + T cells, while NKp44 + NK cells persist in adult intestines. Innate lymphoid cells (ILC), including natural killer (NK) cells, are implicated in host-defense and tissue-growth. However, the composition and kinetics of NK cells in the intestine during the first year of life, when infants are first broadly exposed to exogenous antigens, are still unclear. Here we show that CD103 NK cells are the major ILC population in the small intestines of infants. When compared to adult intestinal NK cells, infant intestinal NK cells exhibit a robust effector phenotype, characterized by Eomes, perforin and granzyme B expression, and superior degranulation capacity. Absolute intestinal NK cell numbers decrease gradually during the first year of life, coinciding with an influx of intestinal Eomes T cells; by contrast, epithelial NKp44 CD69 NK cells with less cytotoxic capacity persist in adults. In conclusion, NK cells are abundant in infant intestines, where they can provide effector functions while Eomes T cell responses mature.
ArticleNumber	975
Author	Perez, Daniel Sagebiel, Adrian F. Lunemann, Sebastian Bunders, Madeleine J. Reinshagen, Konrad Steinert, Fenja Altfeld, Marcus Körner, Christian Schreurs, Renée R. C. E.
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Snippet	Innate lymphoid cells (ILC), including natural killer (NK) cells, are implicated in host-defense and tissue-growth. However, the composition and kinetics of NK... Innate lymphoid cells (ILC), including natural killer (NK) cells, are important innate immune regulators. Here the authors show that, in human infant...
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Title	Tissue-resident Eomes+ NK cells are the major innate lymphoid cell population in human infant intestine
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