Colonization of distant organs by tumor cells generating circulating homotypic clusters adaptive to fluid shear stress

Once disseminated tumor cells (DTCs) arrive at a metastatic organ, they remain there, latent, and become seeds of metastasis. However, the clonal composition of DTCs in a latent state remains unclear. Here, we applied high-resolution DNA barcode tracking to a mouse model that recapitulated the metas...

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Bibliographic Details
Published in:	Scientific reports Vol. 11; no. 1; p. 6150
Main Authors:	Maeshiro, Manabu, Shinriki, Satoru, Liu, Rin, Nakachi, Yutaka, Komohara, Yoshihiro, Fujiwara, Yukio, Ohtsubo, Kazuaki, Yoshida, Ryoji, Iwamoto, Kazuya, Nakayama, Hideki, Matsui, Hirotaka
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 17-03-2021 Nature Publishing Group Nature Portfolio
Subjects:	631/67 631/80 692/4028 Actin Aggregates Animals Anoikis Cell Line Colonization Cytoskeleton Dormancy E-cadherin Fluid flow Head & neck cancer Head and Neck Neoplasms - pathology Humanities and Social Sciences Humans Mechanical stimuli Metastases Metastasis Mice multidisciplinary Myosin Neoplasm Metastasis - pathology Neoplastic Cells, Circulating - pathology Peripheral blood Science Science (multidisciplinary) Seeds Shear stress Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - pathology Tumor cell lines Tumor cells Tumors
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