Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming

Endothelial barrier (EB) breaching is a frequent event during inflammation, and it is followed by the rapid recovery of microvascular integrity. The molecular mechanisms of EB recovery are poorly understood. Triggering of MHC molecules by migrating T-cells is a minimal signal capable of inducing end...

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Bibliographic Details
Published in:	Nature communications Vol. 11; no. 1; p. 3595
Main Authors:	Cheung, Kenneth C. P., Fanti, Silvia, Mauro, Claudio, Wang, Guosu, Nair, Anitha S., Fu, Hongmei, Angeletti, Silvia, Spoto, Silvia, Fogolari, Marta, Romano, Francesco, Aksentijevic, Dunja, Liu, Weiwei, Li, Baiying, Cheng, Lixin, Jiang, Liwen, Vuononvirta, Juho, Poobalasingam, Thanushiyan R., Smith, David M., Ciccozzi, Massimo, Solito, Egle, Marelli-Berg, Federica M.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 17-07-2020 Nature Publishing Group Nature Portfolio
Subjects:	101/28 13/1 13/31 13/51 13/95 14/19 14/28 14/63 631/80 631/80/84 64/60 692/420/256 96/106 Activation AKT protein Animals Antibodies beta Catenin - genetics beta Catenin - metabolism College campuses Contraction Endothelial cells Endothelial Cells - metabolism Endothelium Experiments Female Forkhead Box Protein O1 - genetics Forkhead Box Protein O1 - metabolism FOXO1 protein Glycolysis Homology Humanities and Social Sciences Inflammation Integrity Laboratories Leakage Lymphocytes T Major histocompatibility complex Male Metabolism Mice Microvasculature Microvessels - metabolism Mitochondria Molecular modelling multidisciplinary Permeability Phosphatase Phosphorylation Platelet Endothelial Cell Adhesion Molecule-1 - genetics Platelet Endothelial Cell Adhesion Molecule-1 - metabolism Polymerization Preservation Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Receptors Recovery Science Science (multidisciplinary) Signal Transduction Transcription Translocation β-Catenin
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