Lectican proteoglycans, their cleaving metalloproteinases, and plasticity in the central nervous system extracellular microenvironment

• Published in: Neuroscience Vol. 217; pp. 6 - 18
• Main Authors: Howell, M.D, Gottschall, P.E
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 16-08-2012; Elsevier
• Subjects: ADAMTS; Animals; Biological and medical sciences; Brain - metabolism; chondroitin sulfate proteoglycan; Chondroitin Sulfate Proteoglycans - metabolism; extracellular matrix; Extracellular Matrix - metabolism; Fundamental and applied biological sciences. Psychology; Metalloproteases - metabolism; metalloproteinase; MMP; neural plasticity; Neurology; Neuronal Plasticity - physiology; Neurons - metabolism; Vertebrates: nervous system and sense organs; extracellular signal-regulated kinase; guanosine triphosphate hydrolase; ROCK; tissue plasminogen activator; metalloproteinase; intercellular adhesion molecule 5; ADAMTS; CNS; LTP; ICAM-5; PNN; perineuronal net; receptor protein tyrosine phosphatase σ; chondroitin sulfate proteoglycan; PGs; proteoglycans; RPTPσ; a disintegrin and metalloproteinase with thrombospondin motifs; AD; Alzheimer’s disease; tPA; EGF; neural plasticity; chondroitin sulfate; tissue inhibitors of the metalloproteinases; Rho-associated protein kinase; ECM; central nervous system; CS; MMP; dorsal root ganglion; DRG; matrix metalloproteinase; epidermal growth factor; GTPase; extracellular matrix; ERK; long-term potentiation; TIMP; Proteoglycan; Enzyme; Central nervous system; Metalloendopeptidases; Extracellular; Peptidases; Plasticity; Hydrolases; Extracellular matrix; Chondroitin sulfate; Metalloproteinase
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2012.05.034

Highlights ► Chondroitin sulfate proteoglycans in the brain matrix regulate neural plasticity. ► Extracellular metalloproteinases alter structural and synaptic plasticity. ► These changes may be due to substrate cleavage or perhaps direct action on cells.