Sugar for the brain: the role of glucose in physiological and pathological brain function

Highlights • We provide a comprehensive overview of the role of glucose metabolism in normal brain function. • We analyze the contribution of glucose metabolism to brain physiology. • We discuss controversies in energy substrate consumption and utilization. • We highlight the connection between gluc...

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Bibliographic Details
Published in:	Trends in neurosciences (Regular ed.) Vol. 36; no. 10; pp. 587 - 597
Main Authors:	Mergenthaler, Philipp, Lindauer, Ute, Dienel, Gerald A, Meisel, Andreas
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-10-2013 Elsevier Sequoia S.A
Subjects:	Animals apoptosis Brain - physiology Brain research brain-body axis Energy Metabolism - physiology Glucose Glucose - metabolism Humans Mammals metabolic brain disease metabolic coupling Metabolism Neurology Pathology Physiology metabolic brain disease apoptosis brain-body axis glucose metabolism metabolic coupling
Online Access:	Get full text
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Summary:	Highlights • We provide a comprehensive overview of the role of glucose metabolism in normal brain function. • We analyze the contribution of glucose metabolism to brain physiology. • We discuss controversies in energy substrate consumption and utilization. • We highlight the connection between glucose metabolism and cell death. • We review the pathophysiological consequences of balanced and disturbed glucose metabolism.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0166-2236 1878-108X
DOI:	10.1016/j.tins.2013.07.001