Mechanism of action of and resistance to quinolones

Summary Fluoroquinolones are an important class of wide‐spectrum antibacterial agents. The first quinolone described was nalidixic acid, which showed a narrow spectrum of activity. The evolution of quinolones to more potent molecules was based on changes at positions 1, 6, 7 and 8 of the chemical st...

Full description

Saved in:

Bibliographic Details
Published in:	Microbial biotechnology Vol. 2; no. 1; pp. 40 - 61
Main Authors:	Fàbrega, Anna, Madurga, Sergi, Giralt, Ernest, Vila, Jordi
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-01-2009 John Wiley & Sons, Inc
Subjects:	Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology Antibacterial agents Bacteria Bacteria - drug effects Bacteria - genetics Bacteria - metabolism Bacterial infections Bacterial Proteins - genetics Bacterial Proteins - metabolism Cell division Chromosomes Deoxyribonucleic acid DNA DNA topoisomerase DNA topoisomerase IV Drug Resistance, Bacterial Drugs E coli Efflux Enzymes Fluoroquinolones Gene Expression Regulation, Bacterial Genes Level (quantity) Mutation Nalidixic acid Organic chemistry Plasmids Protein Binding Quinolones Quinolones - metabolism Quinolones - pharmacology Review Rings (mathematics) RNA polymerase Urinary tract diseases Urinary tract infections Urogenital system Viability
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!