One Patient, Two Uncommon B-Cell Neoplasms: Solitary Plasmacytoma following Complete Remission from Intravascular Large B-Cell Lymphoma Involving Central Nervous System

• Published in: Case reports in medicine Vol. 2014; no. 2014; pp. 1 - 6
• Main Authors: Lim, Soon Thye, Farid, Mohamad, Tao, Miriam, Quek, Richard, Tang, Tiffany, Chuah, Khoon Leong, Lee, Hwei Yee, Tan, Leonard H. C., Tan, Soo Yong, Lee, Joycelyn, Tay, Kevin
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01-01-2014; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Care and treatment; Case Report; Case studies; Complications and side effects; Diagnosis; Non-Hodgkin's lymphomas; Patient outcomes; Plasmacytoma; Singapore
• ISSN: 1687-9627; 1687-9635
• DOI: 10.1155/2014/620423

Second lymphoid neoplasms are an uncommon but recognized feature of non-Hodgkin’s lymphomas, putatively arising secondary to common genetic or environmental risk factors. Previous limited evaluations of clonal relatedness between successive mature B-cell malignancies have yielded mixed results. We describe the case of a man with intravascular large B-cell lymphoma involving the central nervous system who went into clinical remission following immunochemotherapy and brain radiation, only to relapse 2 years later with a plasmacytoma of bone causing cauda equina syndrome. The plasmacytoma stained strongly for the cell cycle regulator cyclin D1 on immunohistochemistry, while the original intravascular large cell lymphoma was negative, a disparity providing no support for clonal identity between the 2 neoplasms. Continued efforts atcataloging and evaluating unique associations of B-cell malignancies are critical to improving understanding of overarching disease biology in B-cell malignancies.