Melanoma cells secrete follistatin, an antagonist of activin-mediated growth inhibition

Using a proteomic approach to screen for new growth factors released by melanoma cells, we identified follistatin as a major heparin-binding factor in medium conditioned by the Bowes melanoma cell line. Since follistatin is primarily studied in relation to its neutralization of activin, a member of...

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Bibliographic Details
Published in:	Oncogene Vol. 23; no. 31; pp. 5330 - 5339
Main Authors:	STOVE, Christophe, VANROBAEYS, Frank, DEVREESE, Bart, VAN BEEUMEN, Jozef, MAREEL, Marc, BRACKE, Marc
Format:	Journal Article
Language:	English
Published:	Basingstoke Nature Publishing 08-07-2004 Nature Publishing Group
Subjects:	Activin receptors Activin Receptors - metabolism Activins - metabolism Ageing, cell death Amino Acid Sequence Annexin A5 - biosynthesis Apoptosis Biological and medical sciences Blotting, Western Cell Division Cell Line, Tumor Cell lines Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Dermatology Dose-Response Relationship, Drug Follistatin Follistatin - biosynthesis Fundamental and applied biological sciences. Psychology Genes Genes, Reporter Growth factors Heparin Humans Immunoblotting Kinases Ligands Luciferases - metabolism Mass Spectrometry Medical sciences Melanocytes Melanocytes - metabolism Melanoma Melanoma - metabolism Molecular and cellular biology Molecular Sequence Data Nuclear medicine Phosphorylation Protein Structure, Tertiary Proteomics Radiation therapy Retroviridae - genetics Reverse Transcriptase Polymerase Chain Reaction Secretion Signal Transduction Smad protein Time Factors Transforming growth factor-b Tumors of the skin and soft tissue. Premalignant lesions Belgium Smad protein Growth Malignant melanoma follistatin melanoma Smad Malignant tumor Antagonist Inhibition Activin Carcinogenesis Apoptosis
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