Systemic gene delivery transduces the enteric nervous system of guinea pigs and cynomolgus macaques

Characterization of adeno-associated viral vector (AAV) mediated gene delivery to the enteric nervous system (ENS) was recently described in mice and rats. In these proof-of-concept experiments, we show that intravenous injections of clinically relevant AAVs can transduce the ENS in guinea pigs and...

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Bibliographic Details
Published in:	Gene therapy Vol. 24; no. 10; pp. 640 - 648
Main Authors:	Gombash, S E, Cowley, C J, Fitzgerald, J A, Lepak, C A, Neides, M G, Hook, K, Todd, L J, Wang, G-D, Mueller, C, Kaspar, B K, Bielefeld, E C, Fischer, A J, Wood, J D, Foust, K D
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-10-2017 Nature Publishing Group
Subjects:	14/35 42/34 631/1647/2300 631/378/1959 631/378/1959/1315/1951 631/378/87 692/700/565/201 82/51 82/80 Anatomy Animal tissues Animals Biomedical and Life Sciences Biomedicine Cell Biology Dependovirus - genetics Digestive system Dorsal root ganglia Dosage and administration Enteric nervous system Enteric Nervous System - metabolism Expression vectors Female Ganglia, Spinal - cytology Ganglia, Spinal - metabolism Gastrointestinal tract Gene Expression Gene Therapy Gene transfer Gene Transfer Techniques Genetic modification Genetic Therapy - methods Genetic Vectors - genetics Genetics Genome editing Green fluorescent protein Green fluorescent proteins Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Guinea Pigs Human Genetics Information processing Injection Injections, Intravenous Intravenous administration Intravenous injections Large intestine Macaca fascicularis Macaques Male Motor nuclei Nanotechnology Neonates Nervous system Neurons Neurons - metabolism Optics original-article Phosphates Primates Rats Rodents Stomach Vagus Nerve - metabolism Guinea
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