Gravireceptors in eukaryotes—a comparison of case studies on the cellular level

• Published in: NPJ microgravity Vol. 3; no. 1; pp. 13 - 8
• Main Authors: Häder, Donat-P., Braun, Markus, Grimm, Daniela, Hemmersbach, Ruth
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 28-04-2017; Nature Publishing Group; Nature Portfolio
• Subjects: 631/181; 631/80; Algae; Applied Microbiology; Biomedical and Life Sciences; Biotechnology; Calcium-binding protein; Calmodulin; Classical and Continuum Physics; Cytoskeleton; Environmental conditions; Gene expression; Immunology; Life Sciences; Plant cells; Review; Review Article; Sensory transduction; Space Exploration and Astronautics; Space Sciences (including Extraterrestrial Physics
• ISSN: 2373-8065; 2373-8065
• DOI: 10.1038/s41526-017-0018-8

We have selected five evolutionary very different biological systems ranging from unicellular protists via algae and higher plants to human cells showing responses to the gravity vector of the Earth in order to compare their graviperception mechanisms. All these systems use a mass, which may either by a heavy statolith or the whole content of the cell heavier than the surrounding medium to operate on a gravireceptor either by exerting pressure or by pulling on a cytoskeletal element. In many cases the receptor seems to be a mechanosensitive ion channel activated by the gravitational force which allows a gated ion flux across the membrane when activated. This has been identified in many systems to be a calcium current, which in turn activates subsequent elements of the sensory transduction chain, such as calmodulin, which in turn results in the activation of ubiquitous enzymes, gene expression activation or silencing. Naturally, the subsequent responses to the gravity stimulus differ widely between the systems ranging from orientational movement and directed growth to physiological reactions and adaptation to the environmental conditions.