Genetic Profile of Ductal Adenocarcinoma of the Prostate

• Published in: Human pathology Vol. 69; pp. 1 - 7
• Main Authors: Seipel, Amanda H, MD, PhD, Whitington, Thomas, BSc, PhD, Delahunt, Brett, ONZM, KStJ, MD,FRSNZ, Samaratunga, Hemamali, MBBS,LRCP,MRCS,FRCPA, Mayrhofer, Markus, PhD, Wiklund, Peter, MD, PhD, Grönberg, Henrik, MD, PhD, Lindberg, Johan, MSc, PhD, Egevad, Lars, MD, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-11-2017; Elsevier Limited
• Subjects: Adenocarcinoma; Aged; Biomarkers, Tumor - genetics; Cancer surgery; Carcinoma, Ductal - genetics; Carcinoma, Ductal - secondary; Deoxyribonucleic acid; DNA; DNA Copy Number Variations; DNA Mutational Analysis; Ductal cancer; Gene Dosage; Gene Expression Profiling - methods; Genes; Genetic Predisposition to Disease; Genetics; Genomes; Genomics; Humans; INDEL Mutation; Library collections; Male; Medical prognosis; Medicin och hälsovetenskap; Metastasis; Middle Aged; Morphology; Mutation; Neoplasm Grading; Neoplasm Invasiveness; Neoplasm Staging; Pathology; Phenotype; Prostate cancer; Prostatectomy; Prostatic Neoplasms - genetics; Prostatic Neoplasms - pathology; Prostatic Neoplasms, Castration-Resistant - genetics; Prostatic Neoplasms, Castration-Resistant - pathology; Proteomics; Studies; Transcriptome; Tumor Burden; Tumors; Urological surgery; Prostatectomy; adenocarcinoma; prostate cancer; pathology; genetics; ductal cancer; Adenocarcinoma; Pathology; Genetics; Prostate cancer; Ductal cancer
• ISSN: 0046-8177; 1532-8392; 1532-8392
• DOI: 10.1016/j.humpath.2017.04.015

Summary Despite being discovered almost 50 years ago little is known regarding the genetic profile of ductal adenocarcinoma of the prostate (DAC). In recent years, progress has been made in the understanding of the genetics of acinar adenocarcinomas and at least seven genetically different subtypes have been identified. DAC is known to present at an advanced stage with a high rate of extraprostatic extension and seminal vesicle invasion, and a decreased interval to biochemical recurrence and the development of metastatic disease, when compared to acinar adenocarcinoma. Our aim was to investigate the genetic profile of DAC to determine whether there is a genomic rationale for the aggressive behaviour associated with this tumor type. Frozen tissue from 11 cases of DAC with paired benign tissue was analysed. After DNA extraction, copy-number alteration analysis was performed, as well as identification of mutations and indels. We compared the fraction of the DAC genome with copy-number alteration to previous results from 74 primary acinar adenocarcinomas of the prostate. The alteration rate in DAC was comparable to that of acinar adenocarcinoma of high Gleason score. DAC harbored somatic changes seen in advanced and/or metastatic castration-resistant acinar adenocarcinoma, which likely accounts for its aggressive biological behavior.