Wireless Optogenetic Stimulation of Oxytocin Neurons in a Semi-natural Setup Dynamically Elevates Both Pro-social and Agonistic Behaviors

Wireless Optogenetic Stimulation of Oxytocin Neurons in a Semi-natural Setup Dynamically Elevates Both Pro-social and Agonistic Behaviors

Complex behavioral phenotyping techniques are becoming more prevalent in the field of behavioral neuroscience, and thus methods for manipulating neuronal activity must be adapted to fit into such paradigms. Here, we present a head-mounted, magnetically activated device for wireless optogenetic manip...

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Published in:Neuron (Cambridge, Mass.) Vol. 107; no. 4; pp. 644 - 655.e7
Main Authors: Anpilov, Sergey, Shemesh, Yair, Eren, Noa, Harony-Nicolas, Hala, Benjamin, Asaf, Dine, Julien, Oliveira, Vinícius E.M., Forkosh, Oren, Karamihalev, Stoyo, Hüttl, Rosa-Eva, Feldman, Noa, Berger, Ryan, Dagan, Avi, Chen, Gal, Neumann, Inga D., Wagner, Shlomo, Yizhar, Ofer, Chen, Alon
Format: Journal Article Web Resource
Language:English
Published: United States Elsevier Inc 19-08-2020
Elsevier Limited
Cell Press
Subjects:
aggression
Agonistic Behavior - physiology
Anatomie (cytologie, histologie, embryologie...) & physiologie
Anatomy (cytology, histology, embryology...) & physiology
Animals
Behavior
Behavior, Animal - physiology
Brain
Dental cement
Life sciences
Light emitting diodes
Mice
Nervous system
Neuromodulation
Neurons - metabolism
Neurons - physiology
Neurons/metabolism/physiology
Optics
optogenetics
Optogenetics - methods
Oxytocin
Oxytocin - metabolism
Phenotyping
Power supply
Sciences du vivant
Social Behavior
social salience
wireless
Wireless Technology
oxytocin
social salience
wireless
aggression
social behavior
optogenetics
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Abstract Complex behavioral phenotyping techniques are becoming more prevalent in the field of behavioral neuroscience, and thus methods for manipulating neuronal activity must be adapted to fit into such paradigms. Here, we present a head-mounted, magnetically activated device for wireless optogenetic manipulation that is compact, simple to construct, and suitable for use in group-living mice in an enriched semi-natural arena over several days. Using this device, we demonstrate that repeated activation of oxytocin neurons in male mice can have different effects on pro-social and agonistic behaviors, depending on the social context. Our findings support the social salience hypothesis of oxytocin and emphasize the importance of the environment in the study of social neuromodulators. Our wireless optogenetic device can be easily adapted for use in a variety of behavioral paradigms, which are normally hindered by tethered light delivery or a limited environment. [Display omitted] •A small, wireless device is used for optogenetic activation in a complex environment•PVN oxytocin neurons were activated repeatedly over 2 days in a group setting•Repeated activation in a group setting elicited both pro-social and agonistic behavior•Findings support the social salience hypothesis of oxytocin neuro-modulation Anpilov et al. present a lightweight, easily assembled wireless optogenetic device compatible with group-housed mice in a complex environment. Using this approach, they show that repeated activation of oxytocin neurons elicits both pro-social and aggressive behaviors over time, emphasizing the role of the social setting in modulating behavior.
AbstractList Complex behavioral phenotyping techniques are becoming more prevalent in the field of behavioral neuroscience, and thus methods for manipulating neuronal activity must be adapted to fit into such paradigms. Here, we present a head-mounted, magnetically activated device for wireless optogenetic manipulation that is compact, simple to construct, and suitable for use in group-living mice in an enriched semi-natural arena over several days. Using this device, we demonstrate that repeated activation of oxytocin neurons in male mice can have different effects on pro-social and agonistic behaviors, depending on the social context. Our findings support the social salience hypothesis of oxytocin and emphasize the importance of the environment in the study of social neuromodulators. Our wireless optogenetic device can be easily adapted for use in a variety of behavioral paradigms, which are normally hindered by tethered light delivery or a limited environment.
Complex behavioral phenotyping techniques are becoming more prevalent in the field of behavioral neuroscience, and thus methods for manipulating neuronal activity must be adapted to fit into such paradigms. Here, we present a head-mounted, magnetically activated device for wireless optogenetic manipulation that is compact, simple to construct, and suitable for use in group-living mice in an enriched semi-natural arena over several days. Using this device, we demonstrate that repeated activation of oxytocin neurons in male mice can have different effects on pro-social and agonistic behaviors, depending on the social context. Our findings support the social salience hypothesis of oxytocin and emphasize the importance of the environment in the study of social neuromodulators. Our wireless optogenetic device can be easily adapted for use in a variety of behavioral paradigms, which are normally hindered by tethered light delivery or a limited environment. [Display omitted] •A small, wireless device is used for optogenetic activation in a complex environment•PVN oxytocin neurons were activated repeatedly over 2 days in a group setting•Repeated activation in a group setting elicited both pro-social and agonistic behavior•Findings support the social salience hypothesis of oxytocin neuro-modulation Anpilov et al. present a lightweight, easily assembled wireless optogenetic device compatible with group-housed mice in a complex environment. Using this approach, they show that repeated activation of oxytocin neurons elicits both pro-social and aggressive behaviors over time, emphasizing the role of the social setting in modulating behavior.
SummaryComplex behavioral phenotyping techniques are becoming more prevalent in the field of behavioral neuroscience, and thus methods for manipulating neuronal activity must be adapted to fit into such paradigms. Here, we present a head-mounted, magnetically activated device for wireless optogenetic manipulation that is compact, simple to construct, and suitable for use in group-living mice in an enriched semi-natural arena over several days. Using this device, we demonstrate that repeated activation of oxytocin neurons in male mice can have different effects on pro-social and agonistic behaviors, depending on the social context. Our findings support the social salience hypothesis of oxytocin and emphasize the importance of the environment in the study of social neuromodulators. Our wireless optogenetic device can be easily adapted for use in a variety of behavioral paradigms, which are normally hindered by tethered light delivery or a limited environment.
Complex behavioral phenotyping techniques are becoming more prevalent in the field of behavioral neuroscience, and thus methods for manipulating neuronal activity must be adapted to fit into such paradigms. Here, we present a head-mounted, magnetically activated device for wireless optogenetic manipulation that is compact, simple to construct, and suitable for use in group-living mice in an enriched semi-natural arena over several days. Using this device, we demonstrate that repeated activation of oxytocin neurons in male mice can have different effects on pro-social and agonistic behaviors, depending on the social context. Our findings support the social salience hypothesis of oxytocin and emphasize the importance of the environment in the study of social neuromodulators. Our wireless optogenetic device can be easily adapted for use in a variety of behavioral paradigms, which are normally hindered by tethered light delivery or a limited environment. • A small, wireless device is used for optogenetic activation in a complex environment • PVN oxytocin neurons were activated repeatedly over 2 days in a group setting • Repeated activation in a group setting elicited both pro-social and agonistic behavior • Findings support the social salience hypothesis of oxytocin neuro-modulation Anpilov et al. present a lightweight, easily assembled wireless optogenetic device compatible with group-housed mice in a complex environment. Using this approach, they show that repeated activation of oxytocin neurons elicits both pro-social and aggressive behaviors over time, emphasizing the role of the social setting in modulating behavior.
Author Karamihalev, Stoyo
Benjamin, Asaf
Oliveira, Vinícius E.M.
Eren, Noa
Neumann, Inga D.
Wagner, Shlomo
Berger, Ryan
Chen, Alon
Anpilov, Sergey
Dine, Julien
Shemesh, Yair
Yizhar, Ofer
Hüttl, Rosa-Eva
Harony-Nicolas, Hala
Chen, Gal
Feldman, Noa
Forkosh, Oren
Dagan, Avi
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  organization: Department of Neurobiology, Weizmann Institute of Science, Rehovot 7610001, Israel
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  email: alon.chen@weizmann.ac.il
  organization: Department of Neurobiology, Weizmann Institute of Science, Rehovot 7610001, Israel
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32544386$$D View this record in MEDLINE/PubMed
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Issue 4
Keywords oxytocin
social salience
wireless
aggression
social behavior
optogenetics
Language English
License This is an open access article under the CC BY-NC-ND license.
Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
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PublicationDate 2020-08-19
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PublicationDate_xml – month: 08
  year: 2020
  text: 2020-08-19
  day: 19
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: Cambridge
PublicationTitle Neuron (Cambridge, Mass.)
PublicationTitleAlternate Neuron
PublicationYear 2020
Publisher Elsevier Inc
Elsevier Limited
Cell Press
Publisher_xml – name: Elsevier Inc
– name: Elsevier Limited
– name: Cell Press
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RestrictionsOnAccess open access
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Snippet Complex behavioral phenotyping techniques are becoming more prevalent in the field of behavioral neuroscience, and thus methods for manipulating neuronal...
SummaryComplex behavioral phenotyping techniques are becoming more prevalent in the field of behavioral neuroscience, and thus methods for manipulating...
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SubjectTerms aggression
Agonistic Behavior - physiology
Anatomie (cytologie, histologie, embryologie...) & physiologie
Anatomy (cytology, histology, embryology...) & physiology
Animals
Behavior
Behavior, Animal - physiology
Brain
Dental cement
Life sciences
Light emitting diodes
Mice
Nervous system
Neuromodulation
Neurons - metabolism
Neurons - physiology
Neurons/metabolism/physiology
Optics
optogenetics
Optogenetics - methods
Oxytocin
Oxytocin - metabolism
Phenotyping
Power supply
Sciences du vivant
Social Behavior
social salience
wireless
Wireless Technology
Title Wireless Optogenetic Stimulation of Oxytocin Neurons in a Semi-natural Setup Dynamically Elevates Both Pro-social and Agonistic Behaviors
URI https://dx.doi.org/10.1016/j.neuron.2020.05.028
https://www.ncbi.nlm.nih.gov/pubmed/32544386
https://www.proquest.com/docview/2435518997
https://search.proquest.com/docview/2414409905
http://orbi.ulg.ac.be/handle/2268/260515
https://pubmed.ncbi.nlm.nih.gov/PMC7447984
Volume 107
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