RUFY3 regulates endolysosomes perinuclear positioning, antigen presentation and migration in activated phagocytes

Endo-lysosomes transport along microtubules and clustering in the perinuclear area are two necessary steps for microbes to activate specialized phagocyte functions. We report that RU N and FY VE domain-containing protein 3 (RUFY3) exists as two alternative isoforms distinguishable by the presence of...

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Bibliographic Details
Published in:	Nature communications Vol. 14; no. 1; pp. 4290 - 20
Main Authors:	Char, Rémy, Liu, Zhuangzhuang, Jacqueline, Cédric, Davieau, Marion, Delgado, Maria-Graciela, Soufflet, Clara, Fallet, Mathieu, Chasson, Lionel, Chapuy, Raphael, Camosseto, Voahirana, Strock, Eva, Rua, Rejane, Almeida, Catarina R., Su, Bing, Lennon-Duménil, Ana-Maria, Nal, Beatrice, Roquilly, Antoine, Liang, Yinming, Méresse, Stéphane, Gatti, Evelina, Pierre, Philippe
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 18-07-2023 Nature Publishing Group Nature Portfolio
Subjects:	13/106 13/51 14/19 38 38/62 38/77 38/89 42/41 631/250/21/1293 631/80/313/1776 692/699/255/1318 82/1 96/31 Animals Antigen Presentation Antigens Autophagy Cell activation Clustering Cytoskeleton Endosomes - metabolism Humanities and Social Sciences Immune response Immune system Inactivation Isoforms Leukocyte migration Life Sciences Lipopolysaccharides Lipopolysaccharides - metabolism Lysosomes Lysosomes - metabolism Macrophages Major histocompatibility complex Mice Microorganisms Microtubules multidisciplinary Organelles Phagocytes Phagocytosis Phosphatidylinositol 3-phosphate Proteins Salmonella Science Science (multidisciplinary) γ-Interferon Bacterial infection Antigen-presenting cells Endosomes
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