Could Metabolic Syndrome, Lipodystrophy, and Aging Be Mesenchymal Stem Cell Exhaustion Syndromes?
One of the most important and complex diseases of modern society is metabolic syndrome. This syndrome has not been completely understood, and therefore an effective treatment is not available yet. We propose a possible stem cell mechanism involved in the development of metabolic syndrome. This way o...
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| Published in: | Stem cells international Vol. 2011; no. 2011; pp. 1 - 10 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Cairo, Egypt
Hindawi Puplishing Corporation
01-01-2011
SAGE-Hindawi Access to Research John Wiley & Sons, Inc Hindawi Limited |
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| Abstract | One of the most important and complex diseases of modern society is metabolic syndrome. This syndrome has not been completely understood, and therefore an effective treatment is not available yet. We propose a possible stem cell mechanism involved in the development of metabolic syndrome. This way of thinking lets us consider also other significant pathologies that could have similar etiopathogenic pathways, like lipodystrophic syndromes, progeria, and aging. All these clinical situations could be the consequence of a progressive and persistent stem cell exhaustion syndrome (SCES). The main outcome of this SCES would be an irreversible loss of the effective regenerative mesenchymal stem cells (MSCs) pools. In this way, the normal repairing capacities of the organism could become inefficient. Our point of view could open the possibility for a new strategy of treatment in metabolic syndrome, lipodystrophic syndromes, progeria, and even aging: stem cell therapies. |
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| AbstractList | One of the most important and complex diseases of modern society is metabolic syndrome. This syndrome has not been completely understood, and therefore an effective treatment is not available yet. We propose a possible stem cell mechanism involved in the development of metabolic syndrome. This way of thinking lets us consider also other significant pathologies that could have similar etiopathogenic pathways, like lipodystrophic syndromes, progeria, and aging. All these clinical situations could be the consequence of a progressive and persistent stem cell exhaustion syndrome (SCES). The main outcome of this SCES would be an irreversible loss of the effective regenerative mesenchymal stem cells (MSCs) pools. In this way, the normal repairing capacities of the organism could become inefficient. Our point of view could open the possibility for a new strategy of treatment in metabolic syndrome, lipodystrophic syndromes, progeria, and even aging: stem cell therapies. One of the most important and complex diseases of modern society is metabolic syndrome. This syndrome has not been completely understood, and therefore an effective treatment is not available yet. We propose a possible stem cell mechanism involved in the development of metabolic syndrome. This way of thinking lets us consider also other significant pathologies that could have similar etiopathogenic pathways, like lipodystrophic syndromes, progeria, and aging. All these clinical situations could be the consequence of a progressive and persistent stem cell exhaustion syndrome (SCES). The main outcome of this SCES would be an irreversible loss of the effective regenerative mesenchymal stem cells (MSCs) pools. In this way, the normal repairing capacities of the organism could become inefficient. Our point of view could open the possibility for a new strategy of treatment in metabolic syndrome, lipodystrophic syndromes, progeria, and even aging: stem cell therapies. |
| Audience | Academic |
| Author | Tau, José María Soratti, Carlos Marin, Gustavo Horacio Ibar, Ricardo Spretz, Rubén Patel, Amit Larsen, Gustavo Roque, Gustavo van Leeuwen, Michiel Drago, Hugo Sturla, Flavio Ichim, Thomas Zambón, Daniel Mártire, Karina Díaz Aquino, Vanina Mansilla, Eduardo Riordan, Neil H. Maceira, Alberto Núñez, Luis |
| AuthorAffiliation | 5 Division Skin Bank, Burns Hospital, Buenos Aires City, C1424BSD, Argentina 2 Lipid Clinic, Division of Endocrinology, Hospital Clinic, 08036 Barcelona, Spain 7 Bio-Target, Division of Nanotechnology, NE 68339, USA 4 Division of Cardiothoracic Surgery, University of Utah, Salt Lake City, UT 84132, USA 10 INCUCAI, Presidency, Ministry of Health, 2250-C1428BAJ Buenos Aires, Argentina 9 Nanovogue Inc., Division of Intelligent Matrices, Chicago, IL 60126-2731, USA 6 LNK Chemsolutions, Division of Nanotechnology, Lincoln, NE 68521, USA 1 Tissue Engineering, Regenerative Medicine and Cell Therapies Laboratory, CUCAIBA, Ministry of Health, Province of Buenos Aires, 1900 La Plata, Argentina 3 Division of Endometrial Regenerative Stem Cells, Medistem Inc., San Diego, CA 92122, USA 8 The University of Chicago, Division of Nanotechnology, Chicago, IL 60637, USA 11 Vrije Universiteit, Burns Division, 1081 HV Amsterdam, The Netherlands |
| AuthorAffiliation_xml | – name: 1 Tissue Engineering, Regenerative Medicine and Cell Therapies Laboratory, CUCAIBA, Ministry of Health, Province of Buenos Aires, 1900 La Plata, Argentina – name: 4 Division of Cardiothoracic Surgery, University of Utah, Salt Lake City, UT 84132, USA – name: 7 Bio-Target, Division of Nanotechnology, NE 68339, USA – name: 2 Lipid Clinic, Division of Endocrinology, Hospital Clinic, 08036 Barcelona, Spain – name: 6 LNK Chemsolutions, Division of Nanotechnology, Lincoln, NE 68521, USA – name: 9 Nanovogue Inc., Division of Intelligent Matrices, Chicago, IL 60126-2731, USA – name: 8 The University of Chicago, Division of Nanotechnology, Chicago, IL 60637, USA – name: 3 Division of Endometrial Regenerative Stem Cells, Medistem Inc., San Diego, CA 92122, USA – name: 11 Vrije Universiteit, Burns Division, 1081 HV Amsterdam, The Netherlands – name: 5 Division Skin Bank, Burns Hospital, Buenos Aires City, C1424BSD, Argentina – name: 10 INCUCAI, Presidency, Ministry of Health, 2250-C1428BAJ Buenos Aires, Argentina |
| Author_xml | – sequence: 1 fullname: Mártire, Karina – sequence: 2 fullname: Marin, Gustavo Horacio – sequence: 3 fullname: Zambón, Daniel – sequence: 4 fullname: Díaz Aquino, Vanina – sequence: 5 fullname: Mansilla, Eduardo – sequence: 6 fullname: Roque, Gustavo – sequence: 7 fullname: Ichim, Thomas – sequence: 8 fullname: Riordan, Neil H. – sequence: 9 fullname: Patel, Amit – sequence: 10 fullname: Sturla, Flavio – sequence: 11 fullname: Larsen, Gustavo – sequence: 12 fullname: Spretz, Rubén – sequence: 13 fullname: Núñez, Luis – sequence: 14 fullname: Soratti, Carlos – sequence: 15 fullname: Ibar, Ricardo – sequence: 16 fullname: van Leeuwen, Michiel – sequence: 17 fullname: Tau, José María – sequence: 18 fullname: Drago, Hugo – sequence: 19 fullname: Maceira, Alberto |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21716667$$D View this record in MEDLINE/PubMed |
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| Contributor | Tau, José María Soratti, Carlos Marin, Gustavo Horacio Ibar, Ricardo Spretz, Rubén Patel, Amit Larsen, Gustavo Roque, Gustavo van Leeuwen, Michiel Drago, Hugo Sturla, Flavio Ichim, Thomas Zambón, Daniel Mártire, Karina Díaz Aquino, Vanina Mansilla, Eduardo Maceira, Alberto Riordan, Neil H Núñez, Luis |
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| Copyright | Copyright © 2011 Eduardo Mansilla et al. COPYRIGHT 2011 John Wiley & Sons, Inc. Copyright © 2011 Eduardo Mansilla et al. 2011 |
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| Title | Could Metabolic Syndrome, Lipodystrophy, and Aging Be Mesenchymal Stem Cell Exhaustion Syndromes? |
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