AAV‐mediated gene transfer of DNase I in the liver of mice with colorectal cancer reduces liver metastasis and restores local innate and adaptive immune response

Liver metastasis is a major cause of colorectal cancer‐related death. Although DNase I displays antimetastatic activity by inhibition of NETs, its clinical use is limited due to its short biologic half‐life. AAV‐mediated gene expression of DNase I is a novel therapeutic strategy that could reduce th...

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Bibliographic Details
Published in:	Molecular oncology Vol. 14; no. 11; pp. 2920 - 2935
Main Authors:	Xia, Yujia, He, Jiayi, Zhang, Hongji, Wang, Han, Tetz, George, Maguire, Casey A., Wang, Yu, Onuma, Amblessed, Genkin, Dmitry, Tetz, Victor, Stepanov, Alexey, Terekhov, Stanislav, Ukrainskaya, Valeria, Huang, Hai, Tsung, Allan
Format:	Journal Article
Language:	English
Published:	United States John Wiley & Sons, Inc 01-11-2020 John Wiley and Sons Inc Wiley
Subjects:	Actin Adaptive immunity Adenocarcinoma adeno‐associated virus Animal models Apolipoprotein E Bevacizumab Cancer Cancer therapies Chemotherapy Colorectal cancer Colorectal carcinoma Deoxyribonuclease Deoxyribonuclease I Deoxyribonucleic acid DNA Drug dosages Drug resistance Gene therapy Gene transfer Genes Genetic aspects Health aspects Hepatitis Immune response Inflammation Innate immunity Liver Liver cancer Metastases Metastasis metastatic colorectal cancer Monoclonal antibodies neutrophil extracellular traps Neutrophils Nucleases Post-transcription Proteins Scientific equipment and supplies industry T cells Targeted cancer therapy Veins & arteries United States California United States > US China metastatic colorectal cancer adeno-associated virus Deoxyribonuclease I neutrophil extracellular traps
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