Effective active vaccination against methamphetamine in female rats

Highlights • Active immunization produces antibodies which can sequester drug in the blood. • Such anti-drug immunotherapy has not been broadly tested in female rats. • A vaccine prevented methamphetamine-induced hyperlocomotion in female rats. • The MH6-KLH candidate vaccine is therefore effective...

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Bibliographic Details
Published in:	Drug and alcohol dependence Vol. 175; pp. 179 - 186
Main Authors:	Nguyen, J.D, Bremer, P.T, Hwang, C.S, Vandewater, S.A, Collins, K.C, Creehan, K.M, Janda, K.D, Taffe, M.A
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier B.V 01-06-2017
Subjects:	Adjuvants, Immunologic - administration & dosage Amphetamine-Related Disorders - prevention & control Animals Female Hemocyanins - administration & dosage Immunization - methods Methamphetamine Methamphetamine - administration & dosage Methamphetamine - adverse effects Psychiatry Rat Rats Rats, Wistar Vaccination - methods Vaccine Vaccines - administration & dosage Vapor inhalation vapor inhalation vaccine rat female methamphetamine Female Vaccine Vapor inhalation Rat Methamphetamine
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Summary:	Highlights • Active immunization produces antibodies which can sequester drug in the blood. • Such anti-drug immunotherapy has not been broadly tested in female rats. • A vaccine prevented methamphetamine-induced hyperlocomotion in female rats. • The MH6-KLH candidate vaccine is therefore effective in both sexes.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0376-8716 1879-0046
DOI:	10.1016/j.drugalcdep.2017.03.005