A Role for Natural Regulatory T Cells in the Pathogenesis of Experimental Cerebral Malaria

Cerebral malaria (CM) is a serious complication of Plasmodium falciparum infection that is responsible for a significant number of deaths in children and nonimmune adults. A failure to control blood parasitemia and subsequent sequestration of parasites to brain microvasculature are thought to be key...

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Bibliographic Details
Published in:	The American journal of pathology Vol. 171; no. 2; pp. 548 - 559
Main Authors:	Amante, Fiona H, Stanley, Amanda C, Randall, Louise M, Zhou, Yonghong, Haque, Ashraful, McSweeney, Karli, Waters, Andrew P, Janse, Chris J, Good, Michael F, Hill, Geoff R, Engwerda, Christian R
Format:	Journal Article
Language:	English
Published:	Bethesda, MD Elsevier Inc 01-08-2007 ASIP American Society for Investigative Pathology
Subjects:	Animals Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Biological and medical sciences Brain - drug effects Brain - parasitology Brain - pathology Female Flow Cytometry Forkhead Transcription Factors - immunology Human protozoal diseases Immunohistochemistry Infectious diseases Interferon-gamma - genetics Interferon-gamma - metabolism Interleukin-10 - genetics Interleukin-10 - metabolism Interleukin-2 Receptor alpha Subunit - immunology Investigative techniques, diagnostic techniques (general aspects) Luciferases - genetics Luciferases - metabolism Lymph Nodes - drug effects Lymph Nodes - immunology Lymph Nodes - parasitology Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Malaria Malaria, Cerebral - etiology Malaria, Cerebral - immunology Malaria, Cerebral - prevention & control Medical sciences Mice Mice, Inbred C57BL Mice, Inbred CBA Mice, Transgenic Parasitemia - complications Parasitemia - prevention & control Parasitic diseases Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Plasmodium berghei - growth & development Plasmodium falciparum Protozoal diseases Regular Reverse Transcriptase Polymerase Chain Reaction Spleen - drug effects Spleen - immunology Spleen - parasitology Survival Analysis T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism T-Lymphocytes, Regulatory - physiology Time Factors Infection Protozoal disease Anatomic pathology Malaria Pathogenesis Pernicious attack T-Lymphocyte Parasitosis Experimental study Regulatory cell
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