Cannabinoid pharmacology: the first 66 years

Research into the pharmacology of individual cannabinoids that began in the 1940s, several decades after the presence of a cannabinoid was first detected in cannabis, is concisely reviewed. Also described is how this pharmacological research led to the discovery of cannabinoid CB1 and CB2 receptors...

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Bibliographic Details
Published in:	British journal of pharmacology Vol. 147; no. S1; pp. S163 - S171
Main Author:	Pertwee, Roger G
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-01-2006 Nature Publishing Nature Publishing Group
Subjects:	2‐arachidonoyl glycerol anandamide Animals autoimpairment autoprotection Biological and medical sciences cannabinoid receptor agonists cannabinoid receptor antagonists Cannabinoid Receptor Modulators - history Cannabinoid Receptor Modulators - physiology cannabinoids Cannabinoids - history Cannabis Drug Tolerance endocannabinoids History, 20th Century History, 21st Century Humans Ligands Mediators and Transmitters Medical sciences Pharmacology. Drug treatments Receptors, Cannabinoid - drug effects Receptors, Cannabinoid - history Agonist Arachidonic acid derivatives Glycerol Endogenous substance Cannabidaceae Cannabinoid cannabinoid receptor antagonists autoprotection Anandamide cannabinoid receptor agonists Cannabis Endocannabinoid Dicotyledones Cannabinoid receptor Angiospermae autoimpairment cannabinoids Spermatophyta endocannabinoids Antagonist 2-arachidonoyl glycerol
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Summary:	Research into the pharmacology of individual cannabinoids that began in the 1940s, several decades after the presence of a cannabinoid was first detected in cannabis, is concisely reviewed. Also described is how this pharmacological research led to the discovery of cannabinoid CB1 and CB2 receptors and of endogenous ligands for these receptors, to the development of CB1‐ and CB2‐selective agonists and antagonists and to the realization that the endogenous cannabinoid system has significant roles in both health and disease, and that drugs which mimic, augment or block the actions of endogenously released cannabinoids must have important therapeutic applications. Some goals for future research are identified. British Journal of Pharmacology (2006) 147, S163–S171. doi:10.1038/sj.bjp.0706406
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0007-1188 1476-5381
DOI:	10.1038/sj.bjp.0706406