Identification of Drugs that Regulate Dermal Stem Cells and Enhance Skin Repair

Here, we asked whether we could identify pharmacological agents that enhance endogenous stem cell function to promote skin repair, focusing on skin-derived precursors (SKPs), a dermal precursor cell population. Libraries of compounds already used in humans were screened for their ability to enhance...

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Bibliographic Details
Published in:	Stem cell reports Vol. 6; no. 1; pp. 74 - 84
Main Authors:	Naska, Sibel, Yuzwa, Scott A., Johnston, Adam P.W., Paul, Smitha, Smith, Kristen M., Paris, Maryline, Sefton, Michael V., Datti, Alessandro, Miller, Freda D., Kaplan, David R.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 12-01-2016 Elsevier
Subjects:	Alprostadil - administration & dosage Alprostadil - pharmacology Animals Animals, Newborn Blotting, Western Cell Differentiation - drug effects Cell Differentiation - genetics Cell Self Renewal - drug effects Cell Self Renewal - genetics Cells, Cultured Culture Media - chemistry Culture Media - pharmacology Gene Expression Profiling - methods Gene Ontology Humans MAP Kinase Signaling System - drug effects Mice NIH 3T3 Cells Oligonucleotide Array Sequence Analysis Pharmaceutical Preparations - administration & dosage Rats Skin - drug effects Skin - metabolism Skin - physiopathology Spheroids, Cellular - drug effects Spheroids, Cellular - metabolism Spheroids, Cellular - physiology Stem Cells - drug effects Stem Cells - metabolism Stem Cells - physiology Trimebutine - administration & dosage Trimebutine - pharmacology Wound Healing - drug effects Wound Healing - genetics
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