Decellularized extracellular matrix microparticles as a vehicle for cellular delivery in a model of anastomosis healing

Extracellular matrix (ECM) materials from animal and human sources have become important materials for soft tissue repair. Microparticles of ECM materials have increased surface area and exposed binding sites compared to sheet materials. Decellularized porcine peritoneum was mechanically dissociated...

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Published in:	Journal of biomedical materials research. Part A Vol. 104; no. 7; pp. 1728 - 1735
Main Authors:	Hoganson, David M., Owens, Gwen E., Meppelink, Amanda M., Bassett, Erik K., Bowley, Chris M., Hinkel, Cameron J., Finkelstein, Eric B., Goldman, Scott M., Vacanti, Joseph P.
Format:	Journal Article
Language:	English
Published:	United States Blackwell Publishing Ltd 01-07-2016 Wiley Subscription Services, Inc
Subjects:	3-D cell culture Anastomosis Anastomosis, Surgical Animals Automotive components Binding sites Bioreactors cell adhesion cell migration Cell Movement Cellular Collagen Drug Delivery Systems - methods Electrochemical machining Exposure Extracellular matrix Extracellular Matrix - metabolism Fibroblasts Fibroblasts - cytology Gravitation Gravity Healing Humans In vitro methods and tests In vitro testing Microparticles Microspheres Models, Biological Paracrine signalling Peritoneum Repair Surface area Surgical implants Sus scrofa Tensile Strength Therapy Viability Wound Healing cell migration microparticles cell adhesion extracellular matrix 3-D cell culture
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Abstract	Extracellular matrix (ECM) materials from animal and human sources have become important materials for soft tissue repair. Microparticles of ECM materials have increased surface area and exposed binding sites compared to sheet materials. Decellularized porcine peritoneum was mechanically dissociated into 200 µm microparticles, seeded with fibroblasts and cultured in a low gravity rotating bioreactor. The cells avidly attached and maintained excellent viability on the microparticles. When the seeded microparticles were placed in a collagen gel, the cells quickly migrated off the microparticles and through the gel. Cells from seeded microparticles migrated to and across an in vitro anastomosis model, increasing the tensile strength of the model. Cell seeded microparticles of ECM material have potential for paracrine and cellular delivery therapies when delivered in a gel carrier. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 1728–1735, 2016.
AbstractList	Extracellular matrix (ECM) materials from animal and human sources have become important materials for soft tissue repair. Microparticles of ECM materials have increased surface area and exposed binding sites compared to sheet materials. Decellularized porcine peritoneum was mechanically dissociated into 200 µm microparticles, seeded with fibroblasts and cultured in a low gravity rotating bioreactor. The cells avidly attached and maintained excellent viability on the microparticles. When the seeded microparticles were placed in a collagen gel, the cells quickly migrated off the microparticles and through the gel. Cells from seeded microparticles migrated to and across an in vitro anastomosis model, increasing the tensile strength of the model. Cell seeded microparticles of ECM material have potential for paracrine and cellular delivery therapies when delivered in a gel carrier. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 1728-1735, 2016. Extracellular matrix (ECM) materials from animal and human sources have become important materials for soft tissue repair. Microparticles of ECM materials have increased surface area and exposed binding sites compared to sheet materials. Decellularized porcine peritoneum was mechanically dissociated into 200 mu m microparticles, seeded with fibroblasts and cultured in a low gravity rotating bioreactor. The cells avidly attached and maintained excellent viability on the microparticles. When the seeded microparticles were placed in a collagen gel, the cells quickly migrated off the microparticles and through the gel. Cells from seeded microparticles migrated to and across an in vitro anastomosis model, increasing the tensile strength of the model. Cell seeded microparticles of ECM material have potential for paracrine and cellular delivery therapies when delivered in a gel carrier. J Biomed Mater Res Part A: 104A: 1728-1735, 2016. Extracellular matrix (ECM) materials from animal and human sources have become important materials for soft tissue repair. Microparticles of ECM materials have increased surface area and exposed binding sites compared to sheet materials. Decellularized porcine peritoneum was mechanically dissociated into 200 µm microparticles, seeded with fibroblasts and cultured in a low gravity rotating bioreactor. The cells avidly attached and maintained excellent viability on the microparticles. When the seeded microparticles were placed in a collagen gel, the cells quickly migrated off the microparticles and through the gel. Cells from seeded microparticles migrated to and across an in vitro anastomosis model, increasing the tensile strength of the model. Cell seeded microparticles of ECM material have potential for paracrine and cellular delivery therapies when delivered in a gel carrier. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 1728–1735, 2016.
Author	Bowley, Chris M. Hoganson, David M. Goldman, Scott M. Meppelink, Amanda M. Bassett, Erik K. Finkelstein, Eric B. Vacanti, Joseph P. Owens, Gwen E. Hinkel, Cameron J.
Author_xml	– sequence: 1 givenname: David M. surname: Hoganson fullname: Hoganson, David M. email: david.hoganson@cardio.chboston.org organization: Department of Cardiac Surgery, Boston Children's Hospital, Massachusetts, Boston – sequence: 2 givenname: Gwen E. surname: Owens fullname: Owens, Gwen E. organization: Graduate Option in Biochemistry and Molecular Biophysics, California Institute of Technology, California, Pasadena – sequence: 3 givenname: Amanda M. surname: Meppelink fullname: Meppelink, Amanda M. organization: Division of Plastic and Reconstructive Surgery, Department of Surgery, Massachusetts General Hospital, Massachusetts, Boston – sequence: 4 givenname: Erik K. surname: Bassett fullname: Bassett, Erik K. organization: Department of Surgery, Center for Regenerative Medicine, Massachusetts General Hospital, Massachusetts, Boston – sequence: 5 givenname: Chris M. surname: Bowley fullname: Bowley, Chris M. organization: DSM Biomedical, Pennsylvania, Exton – sequence: 6 givenname: Cameron J. surname: Hinkel fullname: Hinkel, Cameron J. organization: Department of Biomedical Engineering, Washington University in St. Louis, Missouri – sequence: 7 givenname: Eric B. surname: Finkelstein fullname: Finkelstein, Eric B. organization: Department of Biomedical and Chemical Engineering, Syracuse Biomaterials Institute, Syracuse University, New York, Syracuse – sequence: 8 givenname: Scott M. surname: Goldman fullname: Goldman, Scott M. organization: DSM Biomedical, Pennsylvania, Exton – sequence: 9 givenname: Joseph P. surname: Vacanti fullname: Vacanti, Joseph P. organization: Department of Surgery, Center for Regenerative Medicine, Massachusetts General Hospital, Massachusetts, Boston
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Snippet	Extracellular matrix (ECM) materials from animal and human sources have become important materials for soft tissue repair. Microparticles of ECM materials have...
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SubjectTerms	3-D cell culture Anastomosis Anastomosis, Surgical Animals Automotive components Binding sites Bioreactors cell adhesion cell migration Cell Movement Cellular Collagen Drug Delivery Systems - methods Electrochemical machining Exposure Extracellular matrix Extracellular Matrix - metabolism Fibroblasts Fibroblasts - cytology Gravitation Gravity Healing Humans In vitro methods and tests In vitro testing Microparticles Microspheres Models, Biological Paracrine signalling Peritoneum Repair Surface area Surgical implants Sus scrofa Tensile Strength Therapy Viability Wound Healing
Title	Decellularized extracellular matrix microparticles as a vehicle for cellular delivery in a model of anastomosis healing
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