Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

Despite the importance of epigenetic regulation in neurological disorders, little is known about neuronal chromatin. Cerebellar Purkinje neurons have large and euchromatic nuclei, whereas granule cell nuclei are small and have a more typical heterochromatin distribution. While comparing the abundanc...

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Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) Vol. 324; no. 5929; pp. 929 - 930
Main Authors:	Kriaucionis, Skirmantas, Heintz, Nathaniel
Format:	Journal Article
Language:	English
Published:	Washington, DC American Association for the Advancement of Science 15-05-2009 The American Association for the Advancement of Science
Subjects:	5-Methylcytosine - analogs & derivatives Animals Biological and medical sciences Brain Brain Chemistry Cell Line Cell lines Cell nucleus Cellular biology Cerebellum - chemistry Cerebellum - cytology Chromatin Chromatography, High Pressure Liquid Chromatography, Thin Layer Cytosine - analogs & derivatives Cytosine - analysis Deoxycytidine - analogs & derivatives Deoxycytidine - analysis Deoxyribonucleic acid DNA DNA - chemistry DNA Damage Epigenetics Fundamental and applied biological sciences. Psychology Humans Mass Spectrometry Mice Neurons Nucleic acids Nucleosides Nucleotides Purkinje cells Purkinje Cells - chemistry Vertebrates: nervous system and sense organs Cerebellum Chromatin Cell line Granule neuron DNA Central nervous system Distribution Purkinje neuron Neurological disorder Mass spectrometry Encephalon
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