Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action

Insulin receptor substrate-1 (IRS-1) and IRS-2 are known to transduce and amplify signals emanating from the insulin receptor. Here we show that Grb2-associated binder 1 (Gab1), despite its structural similarity to IRS proteins, is a negative modulator of hepatic insulin action. Liver-specific Gab1...

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Bibliographic Details
Published in:	Nature medicine Vol. 11; no. 5; pp. 567 - 571
Main Authors:	Feng, Gen-Sheng, Bard-Chapeau, Emilie A, Hevener, Andrea L, Long, Shinong, Zhang, Eric E, Olefsky, Jerrold M
Format:	Journal Article
Language:	English
Published:	United States Nature Publishing Group 01-05-2005
Subjects:	Animals Blood Chemical Analysis Blood Glucose DNA Primers Enzyme-Linked Immunosorbent Assay Extracellular Signal-Regulated MAP Kinases - metabolism Genetic Engineering Glucose Tolerance Test Insulin - metabolism Insulin Receptor Substrate Proteins Intracellular Signaling Peptides and Proteins Liver Liver - metabolism Mice Mice, Transgenic Phosphoproteins - genetics Phosphoproteins - metabolism Phosphorylation Protein-Serine-Threonine Kinases - metabolism Proteins Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Signal Transduction - physiology Tyrosine - metabolism
Online Access:	Get full text
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