Nanomedicine for increasing the oral bioavailability of cancer treatments

Oral administration is an appealing route of delivering cancer treatments. However, the gastrointestinal tract is characterized by specific and efficient physical, chemical, and biological barriers that decrease the bioavailability of medications, including chemotherapeutics. In recent decades, the...

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Bibliographic Details
Published in:	Journal of nanobiotechnology Vol. 19; no. 1; p. 354
Main Authors:	Parodi, Alessandro, Buzaeva, Polina, Nigovora, Daria, Baldin, Alexey, Kostyushev, Dmitry, Chulanov, Vladimir, Savvateeva, Lyudmila V, Zamyatnin, Jr, Andrey A
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 30-10-2021 BioMed Central BMC
Subjects:	Administration, Oral Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Bioavailability Biological Availability Biological barriers Biological products Cancer Cancer therapies Cancer treatment Care and treatment Chemotherapy Drug Delivery Systems Drugs Enzymes Food Gastrointestinal system Gastrointestinal tract Humans Immune system Large intestine Medical research Medicine, Experimental Metabolism Molecular weight Nanomedicine Nanotechnology Neoplasms - drug therapy Oral administration Oral medication Oral nanomedicine Pathogens Patients Pharmaceutical Preparations Pharmaceutical sciences Pharmacokinetics Proteins Review Self-medication Small intestine Stomach Technology application Vehicles Russia Cancer treatment Oral nanomedicine Biological barriers
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Summary:	Oral administration is an appealing route of delivering cancer treatments. However, the gastrointestinal tract is characterized by specific and efficient physical, chemical, and biological barriers that decrease the bioavailability of medications, including chemotherapeutics. In recent decades, the fields of material science and nanomedicine have generated several delivery platforms with high potential for overcoming multiple barriers associated to oral administration. This review describes the properties of several nanodelivery systems that improve the bioavailability of orally administered therapeutics, highlighting their advantages and disadvantages in generating successful anticancer oral nanomedicines.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1477-3155 1477-3155
DOI:	10.1186/s12951-021-01100-2