Monocyte transcriptomes from patients with axial spondyloarthritis reveal dysregulated monocytopoiesis and a distinct inflammatory imprint

In patients with axial spondyloarthritis (axSpA), monocytes show a pre-activated phenotype. Gut inflammation is a trigger of monocyte activation and may also affect their development in the bone marrow (BM). As gut inflammation is commonly observed in axSpA patients, we performed a detailed analysis...

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Bibliographic Details
Published in:	Arthritis research & therapy Vol. 23; no. 1; p. 246
Main Authors:	Karow, Fabian, Smiljanovic, Biljana, Grün, Joachim R, Poddubnyy, Denis, Proft, Fabian, Talpin, Alice, Hue, Christophe, Boland, Anne, Deleuze, Jean-François, Garchon, Henri-Jean, Ergenç, Ilkay, De Craemer, Ann-Sophie, Erben, Ulrike, Häupl, Thomas, Elewaut, Dirk, Breban, Maxime, Grützkau, Andreas, Syrbe, Uta
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 24-09-2021 BioMed Central BMC
Subjects:	Arthritis Biochemistry, Molecular Biology Biopsy Clustering Cytokines Diagnosis Gene expression Gene Expression Profiling Genetic aspects Genomics Gut translocation Health aspects Human health and pathology Humans Hypoxia Immunology Independent study Inflammation Innate immunity Life Sciences Monocytes Neutrophils Proteins Rhumatology and musculoskeletal system Serology Spondylarthritis - genetics Spondyloarthritis Spondyloarthropathies Statistical analysis Transcriptome Transcriptomes Germany France Transcriptomes Gut translocation Monocytes Spondyloarthritis
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