Complementary NAD + replacement strategies fail to functionally protect dystrophin-deficient muscle

Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disorder stemming from a loss of functional dystrophin. Current therapeutic options for DMD are limited, as small molecule modalities remain largely unable to decrease the incidence or mitigate the consequences of repetitive mechanica...

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Bibliographic Details
Published in:	Skeletal muscle Vol. 10; no. 1; p. 30
Main Authors:	Frederick, David W, McDougal, Alan V, Semenas, Melisa, Vappiani, Johanna, Nuzzo, Andrea, Ulrich, John C, Becherer, J David, Preugschat, Frank, Stewart, Eugene L, Sévin, Daniel C, Kramer, H Fritz
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 22-10-2020 BioMed Central BMC
Subjects:	Adenine ADP-ribosyl cyclase ADP-ribosyl Cyclase 1 - antagonists & inhibitors Amino acids Animals CD38 CD38 antigen Degeneration Duchenne's muscular dystrophy Dystrophin Dystrophin - deficiency Eccentric Enzymatic activity Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Enzymes Health aspects Injury Intermediates Male MDX Membrane Glycoproteins - antagonists & inhibitors Metabolism Metabolites Metabolome Metabolomics Mice Mice, Inbred C57BL Mice, Inbred mdx Muscle Contraction Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscle, Skeletal - physiology Muscular Dystrophy, Duchenne - drug therapy Muscular Dystrophy, Duchenne - genetics Muscular Dystrophy, Duchenne - metabolism Musculoskeletal system Mutation NAD NAD - metabolism Niacinamide Niacinamide - analogs & derivatives Niacinamide - pharmacology Niacinamide - therapeutic use Pentose phosphate pathway Phenotypes Phosphates Physiological aspects Polyamines Principal components analysis Pyridinium Compounds - pharmacology Pyridinium Compounds - therapeutic use Recovery of function Rodents Utrophin MDX NAD Metabolomics NR Injury Therapeutics CD38 Eccentric
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