CD38‐Specific Gallium‐68 Labeled Peptide Radiotracer Enables Pharmacodynamic Monitoring in Multiple Myeloma with PET

The limited availability of molecularly targeted low‐molecular‐weight imaging agents for monitoring multiple myeloma (MM)‐targeted therapies has been a significant challenge in the field. In response, a first‐in‐class peptide‐based radiotracer, [68Ga]Ga‐AJ206, is developed that can be seamlessly int...

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Bibliographic Details
Published in:	Advanced science Vol. 11; no. 16; pp. e2308617 - n/a
Main Authors:	Sharma, Ajay Kumar, Gupta, Kuldeep, Mishra, Akhilesh, Lofland, Gabriela, Marsh, Ian, Kumar, Dhiraj, Ghiaur, Gabriel, Imus, Philip, Rowe, Steven P., Hobbs, Robert F., Gocke, Christian B., Nimmagadda, Sridhar
Format:	Journal Article
Language:	English
Published:	Germany John Wiley & Sons, Inc 01-04-2024 John Wiley and Sons Inc Wiley
Subjects:	Antigens ATRA Biodistribution Bone marrow Cancer therapies CD38 daratumumab Drug dosages isatuximab Liver Molecular weight Monoclonal antibodies Multiple myeloma Peptides PET Pharmacodynamics Pharmacokinetics Tomography Tumors isatuximab CD38 ATRA daratumumab pharmacodynamics PET
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