Liquid Biopsy of Extracellular Microvesicles Predicts Future Major Ischemic Events in Genetically Characterized Familial Hypercholesterolemia Patients

OBJECTIVE—Circulating microvesicles (cMVs) exert regulatory roles in atherothrombosis. Patients with familial hypercholesterolemia (FH) that are at high risk for premature cardiovascular events (CVEs) have previously shown high levels of cMVs related to disease severity. However, much remains unknow...

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Bibliographic Details
Published in:	Arteriosclerosis, thrombosis, and vascular biology Vol. 39; no. 6; pp. 1172 - 1181
Main Authors:	Suades, Rosa, Padró, Teresa, Crespo, Javier, Sionis, Alessandro, Alonso, Rodrigo, Mata, Pedro, Badimon, Lina
Format:	Journal Article
Language:	English
Published:	United States American Heart Association, Inc 01-06-2019
Subjects:	Biomarkers - blood Blood Platelets - metabolism Blood Platelets - pathology Brain Ischemia - blood Brain Ischemia - genetics Brain Ischemia - mortality Brain Ischemia - pathology Cell-Derived Microparticles - metabolism Cell-Derived Microparticles - pathology Female Genetic Predisposition to Disease Humans Hyperlipoproteinemia Type II - blood Hyperlipoproteinemia Type II - genetics Hyperlipoproteinemia Type II - mortality Hyperlipoproteinemia Type II - pathology Leukocytes - metabolism Leukocytes - pathology Lipids - blood Liquid Biopsy Male Medicin och hälsovetenskap Middle Aged Mutation Myocardial Ischemia - blood Myocardial Ischemia - genetics Myocardial Ischemia - mortality Myocardial Ischemia - pathology Phenotype Predictive Value of Tests Prognosis Risk Assessment Risk Factors Spain Stroke - blood Stroke - genetics Stroke - mortality Stroke - pathology Time Factors Spain mortality leukocytes prognosis biomarkers platelets
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