Interferon-induced ISG15 pathway: an ongoing virus–host battle

Highlights ► ISG15 has antiviral activity and is conjugated to viral proteins during infection. ► Some viral proteins bind ISG15 to counter its antiviral activity. ► NS1B protein of influenza B virus binds only human and non-human primate ISG15s. ► Other viral proteins remove ISG15 from proteins to...

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Bibliographic Details
Published in:	Trends in microbiology (Regular ed.) Vol. 21; no. 4; pp. 181 - 186
Main Authors:	Zhao, Chen, Collins, Mark N, Hsiang, Tien-Ying, Krug, Robert M
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-04-2013
Subjects:	Amino Acid Sequence antiviral properties antiviral proteins Cytokines - immunology enzymes Host-Pathogen Interactions Humans Influenza B virus Influenza B virus - immunology Influenza B virus - pathogenicity interferon interferons Interferons - immunology Internal Medicine ISG15 Models, Molecular Molecular Sequence Data NS1B protein ovarian tumor domain Review Sequence Homology, Amino Acid species specificity ubiquitin Ubiquitins - immunology viruses ISG15 ovarian tumor domain interferon NS1B protein species specificity influenza B virus
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Summary:	Highlights ► ISG15 has antiviral activity and is conjugated to viral proteins during infection. ► Some viral proteins bind ISG15 to counter its antiviral activity. ► NS1B protein of influenza B virus binds only human and non-human primate ISG15s. ► Other viral proteins remove ISG15 from proteins to counter antiviral activity.
Bibliography:	http://dx.doi.org/10.1016/j.tim.2013.01.005 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0966-842X 1878-4380
DOI:	10.1016/j.tim.2013.01.005