Distinct effects of ruxolitinib and interferon-alpha on murine JAK2V617F myeloproliferative neoplasm hematopoietic stem cell populations

JAK2V617F is the most common mutation in patients with BCR-ABL negative myeloproliferative neoplasms (MPNs). The eradication of JAK2V617F hematopoietic stem cells (HSCs) is critical for achieving molecular remissions and cure. We investigate the distinct effects of two therapies, ruxolitinib (JAK1/2...

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Bibliographic Details
Published in:	Leukemia Vol. 34; no. 4; pp. 1075 - 1089
Main Authors:	Austin, Rebecca J., Straube, Jasmin, Bruedigam, Claudia, Pali, Gabor, Jacquelin, Sebastien, Vu, Therese, Green, Joanne, Gräsel, Julius, Lansink, Lianne, Cooper, Leanne, Lee, Shin-Jye, Chen, Nien-Tsu, Lee, Chung-Wei, Haque, Ashraful, Heidel, Florian H., D’Andrea, Richard, Hill, Geoff R., Mullally, Ann, Milsom, Michael D., Bywater, Megan, Lane, Steven W.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-04-2020 Nature Publishing Group
Subjects:	13/100 13/21 13/31 13/95 42/34 42/35 42/41 631/67/71 64/60 692/308/2778 Abl protein Activation Animals Antiviral Agents - pharmacology BCR protein Cancer Research Care and treatment Cell Proliferation Cells, Cultured Critical Care Medicine Damage Deoxyribonucleic acid Development and progression DNA DNA damage Drug Therapy, Combination Female Fusion protein Gene mutations Genetic aspects Health aspects Hematology Hematopoietic stem cells Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - metabolism Hematopoietic Stem Cells - pathology Inhibitor drugs Intensive Interferon Interferon-alpha - pharmacology Internal Medicine Janus kinase Janus Kinase 2 - genetics Male Medicine Medicine & Public Health Mice Mice, Inbred C57BL Mice, Knockout Mutation Myeloproliferative disorders Myeloproliferative Disorders - drug therapy Myeloproliferative Disorders - genetics Myeloproliferative Disorders - pathology Neoplasms Oncology Patient outcomes Patients Phosphorylation Populations Pyrazoles - pharmacology Reactive oxygen species Stat1 protein STAT1 Transcription Factor - genetics STAT1 Transcription Factor - metabolism Stat5 protein Stem cell transplantation Stem cells α-Interferon Australia
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