Wnt Gradient Formation Requires Retromer Function in Wnt-Producing Cells

Wnt proteins function as morphogens that can form long-range concentration gradients to pattern developing tissues. Here, we show that the retromer, a multiprotein complex involved in intracellular protein trafficking, is required for long-range signaling of the Caenorhabditis elegans Wnt ortholog E...

Full description

Saved in:

Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) Vol. 312; no. 5775; pp. 921 - 924
Main Authors:	Coudreuse, Damien Y.M, Roël, Giulietta, Betist, Marco C, Destrée, Olivier, Korswagen, Hendrik C
Format:	Journal Article
Language:	English
Published:	Washington, DC American Association for the Advancement of Science 12-05-2006 The American Association for the Advancement of Science
Subjects:	Animal migration behavior Animals Biological and medical sciences Body Patterning Caenorhabditis elegans Caenorhabditis elegans - cytology Caenorhabditis elegans - genetics Caenorhabditis elegans - growth & development Caenorhabditis elegans - physiology Caenorhabditis elegans Proteins - analysis Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - physiology Cell differentiation, maturation, development, hematopoiesis Cell Line Cell physiology Cellular biology Daughter cells Epithelial cells Fundamental and applied biological sciences. Psychology Gene Expression Genetics Glycoproteins - analysis Glycoproteins - genetics Glycoproteins - physiology Humans Larvae Molecular and cellular biology Multiprotein Complexes - physiology Mutation Neuroblasts Neurons Neurons - cytology Neurons - physiology Phenotypes Proteins RNA Interference Secretion Signal Transduction Transgenes Vertebrates Vesicular Transport Proteins - genetics Vesicular Transport Proteins - physiology Wnt Proteins - physiology Xenopus Caenorhabditis elegans Helmintha Development Nemathelminthia Molecular complex Invertebrata Nematoda Concentration gradient
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!