Brachyury-YAP Regulatory Axis Drives Stemness and Growth in Cancer

Molecular factors that define stem cell identity have recently emerged as oncogenic drivers. For instance, brachyury, a key developmental transcriptional factor, is also implicated in carcinogenesis, most notably of chordoma, through mechanisms that remain elusive. Here, we show that brachyury is a...

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Bibliographic Details
Published in:	Cell reports (Cambridge) Vol. 21; no. 2; pp. 495 - 507
Main Authors:	Shah, Sagar R., David, Justin M., Tippens, Nathaniel D., Mohyeldin, Ahmed, Martinez-Gutierrez, Juan C., Ganaha, Sara, Schiapparelli, Paula, Hamilton, Duane H., Palena, Claudia, Levchenko, Andre, Quiñones-Hinojosa, Alfredo
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 10-10-2017 Elsevier
Subjects:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals brachyury Carcinogenesis - genetics Carcinogenesis - metabolism Carcinoma - genetics Carcinoma - metabolism Cell Line, Tumor Central Nervous System Neoplasms - genetics Central Nervous System Neoplasms - metabolism Chondroma - genetics Chondroma - metabolism Chondroma - pathology chordoma Fetal Proteins - genetics Fetal Proteins - metabolism Gene Expression Regulation, Neoplastic glioblastoma Glioblastoma - genetics Glioblastoma - metabolism Glioblastoma - pathology growth Humans lung carcinoma Lung Neoplasms - genetics Lung Neoplasms - metabolism Mice Neoplastic Stem Cells - metabolism Phosphoproteins - genetics Phosphoproteins - metabolism stremness T-Box Domain Proteins - genetics T-Box Domain Proteins - metabolism Transcription Factors YAP glioblastoma lung carcinoma YAP stremness growth chordoma brachyury
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