Methylmercury and brain development: A review of recent literature

• Published in: Journal of trace elements in medicine and biology Vol. 38; pp. 99 - 107
• Main Authors: Antunes dos Santos, Alessandra, Appel Hort, Mariana, Culbreth, Megan, López-Granero, Caridad, Farina, Marcelo, Rocha, Joao B.T., Aschner, Michael
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01-12-2016
• Subjects: Animals; Brain - drug effects; Brain - metabolism; Calcium - metabolism; Cell Differentiation - drug effects; Cytoskeleton - drug effects; Cytoskeleton - metabolism; Developmental neurotoxicity; Glutamic Acid - metabolism; Humans; Mechanisms; Methylmercury; Methylmercury Compounds - toxicity; Mitochondria - drug effects; Mitochondria - metabolism; Mechanisms; Methylmercury; Developmental neurotoxicity
• ISSN: 0946-672X; 1878-3252
• DOI: 10.1016/j.jtemb.2016.03.001

Methylmercury (MeHg) is a potent environmental pollutant, which elicits significant toxicity in humans. The central nervous system (CNS) is the primary target of toxicity, and is particularly vulnerable during development. Maternal exposure to MeHg via consumption of fish and seafood can have irreversible effects on the neurobehavioral development of children, even in the absence of symptoms in the mother. It is well documented that developmental MeHg exposure may lead to neurological alterations, including cognitive and motor dysfunction. The neurotoxic effects of MeHg on the developing brain have been extensively studied. The mechanism of toxicity, however, is not fully understood. No single process can explain the multitude of effects observed in MeHg-induced neurotoxicity. This review summarizes the most current knowledge on the effects of MeHg during nervous system development considering both, in vitro and in vivo experimental models. Considerable attention was directed towards the role of glutamate and calcium dyshomeostasis, mitochondrial dysfunction, as well as the effects of MeHg on cytoskeletal components/regulators.