Distant Metastasis after Surgery for Encapsulated Papillary Carcinoma of the Breast: A Case Report

• Published in: Case reports in oncology Vol. 13; no. 3; pp. 1196 - 1201
• Main Authors: Kitahara, Miyuki, Hozumi, Yasuo, Takeuchi, Naoto, Ichinohe, Satoko, Fujiwara, Saori, Machinaga, Mitsuki, Saitoh, Hitoaki, Iijima, Tatsuo
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 29-09-2020; Karger Publishers
• Subjects: Biopsy; Breast cancer; Breast diseases; Cancer therapies; Case Report; Case reports; Cellular biology; Classification; Cytokeratin; distant metastasis; ductal carcinoma in situ; encapsulated papillary carcinoma; Endocrine therapy; Estrogens; Lumpectomy; Lymphatic system; Mastectomy; Medical prognosis; Metastasis; Pleural effusion; Radiation therapy; Surgery; Thyroid cancer; Tumors; Distant metastasis; Ductal carcinoma in situ; Breast cancer; Encapsulated papillary carcinoma
• ISSN: 1662-6575; 1662-6575
• DOI: 10.1159/000510308

In the absence of clear interstitial invasion, encapsulated papillary carcinoma (EPC) of the breast may be attributed to an extremely good prognosis if handled similarly to ductal carcinoma in situ (DCIS) with suitable local treatment. Here, we report our experience with a case of EPC of the breast that presented with carcinomatous pleuritis and lymphangitis carcinomatosa postoperatively, which rapidly resulted in a poor outcome. A 67-year-old woman was diagnosed with DCIS of the left breast and underwent left partial mastectomy and sentinel lymph node biopsy. EPC was diagnosed because the pathological examination showed no sign of interstitial infiltration. Postoperative radiation therapy was performed. Five years and 9 months postoperatively, the patient began experiencing cough and shortness of breath on exertion. Imaging showed right pleural effusion and consolidation of the lung field, but nothing suggesting local recurrence in the preserved left breast, local lymph nodes, or opposite breast was observed. Postoperative recurrence of breast cancer, carcinomatous pleuritis, and lymphangitis carcinomatosa were diagnosed based on the results of pleural fluid cytology. One month later, multiple brain metastases were found, and the patient died of the primary disease 5 months after recurrence. After surgery for EPC without clear interstitial infiltration, there was a small possibility of a poor outcome from distant metastasis. Therefore, although distant metastasis is uncommon, regular examination and testing should be performed.