Genome-wide association study of bipolar I disorder in the Han Chinese population

We report the first genome-wide association study in 1000 bipolar I patients and 1000 controls, with a replication of the top hits in another 409 cases and 1000 controls in the Han Chinese population. Four regions with most strongly associated single-nucleotide polymorphisms (SNPs) were detected, of...

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Published in:	Molecular psychiatry Vol. 16; no. 5; pp. 548 - 556
Main Authors:	Lee, M T M, Chen, C H, Lee, C S, Chen, C C, Chong, M Y, Ouyang, W C, Chiu, N Y, Chuo, L J, Chen, C Y, Tan, H K L, Lane, H Y, Chang, T J, Lin, C H, Jou, S H, Hou, Y M, Feng, J, Lai, T J, Tung, C L, Chen, T J, Chang, C J, Lung, F W, Chen, C K, Shiah, I S, Liu, C Y, Teng, P R, Chen, K H, Shen, L J, Cheng, C S, Chang, T P, Li, C F, Chou, C H, Wang, K H T, Fann, C S J, Wu, J Y, Chen, Y T, Cheng, A T A
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-05-2011 Nature Publishing Group
Subjects:	631/208/205/2138 692/699/476/1333 692/700/478/174 Adult and adolescent clinical studies Ankyrins - genetics Armed forces Asian Continental Ancestry Group - ethnology Asian Continental Ancestry Group - genetics Behavioral Sciences Biological and medical sciences Biological Psychology Bipolar disorder Bipolar Disorder - epidemiology Bipolar Disorder - ethnology Bipolar Disorder - genetics Bipolar disorders Calcium channels (voltage-gated) Calcium Channels, L-Type - genetics Chromosome 3 Consortia Disease susceptibility DNA-Binding Proteins - genetics Female Genes Genetic aspects Genetic Predisposition to Disease Genome-wide association studies Genome-Wide Association Study Genomes Genotype Hospitals Humans Male Medical sciences Medicine Medicine & Public Health Mood disorders Neurosciences Odds Ratio original-article Pathogenesis Pharmacotherapy Phenotype Polymorphism, Single Nucleotide - genetics Population studies Potassium Proteins - genetics Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychosis Reproducibility of Results Risk factors Schizophrenia Sialyltransferases - genetics Single nucleotide polymorphisms Single-nucleotide polymorphism Transcription Factors - genetics White people Taiwan China bipolar genome study Mood disorder CACNB2 ST8SIA2 Chinese Bipolar disorder SP8 ANK3 KCTD12
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