Gancao Nourishing-Yin decoction combined with methotrexate in treatment of aging CIA mice: a study based on DIA proteomic analysis

Elderly rheumatoid arthritis (ERA) population faces multiple treatment dilemma. Here we aim to investigate if Gancao Nourishing-Yin decoction (GCNY) added to methotrexate (MTX) exhibit better effects in an ERA mice model. ERA mice model was established by adding D-galactose (Dgal) to collagen-induce...

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Bibliographic Details
Published in:	Chinese medicine Vol. 18; no. 1; p. 9
Main Authors:	Chen, Yong, Zhu, Xing-Wang, Lai, Wing-Fu, Liu, Yong-Pu, Xu, Xuan-Feng, Liu, Li-Ming, Chen, Yan-Juan, Zhang, Chuan-Fu, Wang, Guang-Yi, Cheng, Zhi-Qiang, Liu, Dong-Zhou
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 28-01-2023 BioMed Central BMC
Subjects:	1-Phosphatidylinositol 3-kinase Aging AKT protein Analysis Ankle Arthritis b-Adrenergic-receptor kinase Body fat Cartilage Chinese medicine Collagen D-Galactose Dihydrofolate reductase Drug dosages Folic acid Galactose Geriatrics Immunization Inflammation Integrative treatment Joint diseases Kinases Laboratory animals Methotrexate Osteoclastogenesis Pathology Peptides Phenotypes Proteins Proteomics Rheumatoid arthritis Rheumatoid factor Signal transduction Synergic action Traditional chinese medicine China Integrative treatment Aging Synergic action Traditional chinese medicine Rheumatoid arthritis
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