Telomere states and cell fates

Telomere length has frequently been used as a means to predict the future life of cells. Here recent findings are integrated into a new, probabilistic view of the telomere to explain how and when it can signal not only its own fate but also that of a cell.

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Bibliographic Details
Published in:	Nature (London) Vol. 408; no. 6808; pp. 53 - 56
Main Author:	Blackburn, Elizabeth H
Format:	Journal Article
Language:	English
Published:	London Nature Publishing 02-11-2000 Nature Publishing Group
Subjects:	Ageing, cell death Animals Biochemistry Biological and medical sciences Cell Cycle - physiology Cell physiology Cells Cellular Senescence - genetics Cellular Senescence - physiology Deoxyribonucleic acid DNA DNA Damage Enzymes Fundamental and applied biological sciences. Psychology Genes Humans Kluyveromyces - physiology Mice Microbiology Models, Biological Molecular and cellular biology Saccharomyces cerevisiae - physiology Telomere Signal transduction Chromosome Eucaryote Telomere DNA Apoptosis
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Description
Summary:	Telomere length has frequently been used as a means to predict the future life of cells. Here recent findings are integrated into a new, probabilistic view of the telomere to explain how and when it can signal not only its own fate but also that of a cell.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-3 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0028-0836 1476-4687
DOI:	10.1038/35040500