Release behavior and toxicity profiles towards A549 cell lines of ciprofloxacin from its layered zinc hydroxide intercalation compound

• Published in: BMC chemistry Vol. 7; no. 1; p. 119
• Main Authors: Abdul Latip, Ahmad Faiz, Hussein, Mohd Zobir, Stanslas, Johnson, Wong, Charng Choon, Adnan, Rohana
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 12-07-2013; Springer Nature B.V; BioMed Central
• Subjects: Acids; Anions; Aqueous solutions; Cell culture; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Drug delivery systems; Fourier transforms; Health sciences; Hydroxides; Intercalation compounds; Ion exchangers; Materials and Polymers; Molecular weight; Nanoparticles; Nanostructured materials; Nitrates; Research Article; Texture; Thermogravimetric analysis; Toxicity; Zinc; Zinc oxides; Selangor Malaysia; Malaysia; Layered zinc hydroxide nitrate; Anion exchange; Release mechanisms; Sustained release; Cytotoxicity; Drug delivery; Ciprofloxacin
• ISSN: 1752-153X; 1752-153X; 2661-801X
• DOI: 10.1186/1752-153X-7-119

Background
Layered hydroxides salts (LHS), a layered inorganic compound is gaining attention in a wide range of applications, particularly due to its unique anion exchange properties. In this work, layered zinc hydroxide nitrate (LZH), a family member of LHS was intercalated with anionic ciprofloxacin (CFX), a broad spectrum antibiotic via ion exchange in a mixture solution of water:ethanol.
Results
Powder x-ray diffraction (XRD), Fourier transform infrared (FTIR) and thermogravimetric analysis (TGA) confirmed the drug anions were successfully intercalated in the interlayer space of LZH. Specific surface area of the obtained compound was increased compared to that of the host due to the different pore textures between the two materials. CFX anions were slowly released over 80 hours in phosphate-buffered saline (PBS) solution due to strong interactions that occurred between the intercalated anions and the host lattices. The intercalation compound demonstrated enhanced antiproliferative effects towards A549 cancer cells compared to the toxicity of CFX alone.
Conclusions
Strong host-guest interactions between the LZH lattice and the CFX anion give rise to a new intercalation compound that demonstrates sustained release mode and enhanced toxicity effects towards A549 cell lines. These findings should serve as foundations towards further developments of the brucite-like host material in drug delivery systems.