ppiGReMLIN: a graph mining based detection of conserved structural arrangements in protein-protein interfaces

Protein-protein interactions (PPIs) are fundamental in many biological processes and understanding these interactions is key for a myriad of applications including drug development, peptide design and identification of drug targets. The biological data deluge demands efficient and scalable methods t...

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Bibliographic Details
Published in:	BMC bioinformatics Vol. 21; no. 1; pp. 143 - 25
Main Authors:	Queiroz, Felippe C, Vargas, Adriana M P, Oliveira, Maria G A, Comarela, Giovanni V, Silveira, Sabrina A
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 15-04-2020 BioMed Central BMC
Subjects:	Apoptosis Bcl-2 protein Binding Binding sites Biological activity Conserved sequence Data mining Datasets Drug development Graph representations Graph theory Interaction patterns Interfaces Knowledge discovery Ligands Peptides Physicochemical properties Protease Proteases Protein interaction Protein-protein interaction Protein-protein interactions Proteinase Proteins Residues Serine Soybeans Substructures Suppressors Target recognition Therapeutic targets Trypsin Protein-protein interaction Data mining Interaction patterns
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